{"id":"W3040017923","doi":"10.1016/j.chom.2020.06.021","title":"Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2","year":2020,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":484,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Washington University School of Medicine in St. Louis; Defense Advanced Research Projects Agency; Washington University in St. Louis; National Institutes of Health; Eli Lilly and Company; Vir Biotechnology; Helen Hay Whitney Foundation","keywords":"Biology; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Antibody; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Viral replication; Replication (statistics); Neutralizing antibody; Sars virus; Microbiology; Immunology; Virus; Infectious disease (medical specialty); Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005982759,0.0002642037,0.000754795,0.0001597597,0.00008144716,0.0000391694,0.0001610355,0.0002266775,0.000003414617],"category_scores_gemma":[0.000172929,0.0002526214,0.0002014333,0.0004129671,0.0004180902,0.000147464,0.0002907155,0.0004338645,0.00002582136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003513887,"about_ca_system_score_gemma":0.0002053419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003245581,"about_ca_topic_score_gemma":0.0000215087,"domain_scores_codex":[0.9975052,0.0001134148,0.0009222261,0.0007945269,0.0002661167,0.0003985445],"domain_scores_gemma":[0.9985335,0.0001678784,0.0003365823,0.0006269933,0.0002668237,0.00006814648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005255292,0.0003339119,0.03210878,0.001025176,0.00007155714,0.00003264331,0.0007515944,4.776687e-8,0.9635516,0.000040046,0.001041848,0.0005172698],"study_design_scores_gemma":[0.003073798,0.0008917758,0.007849759,0.000281183,0.0001412968,0.00004658248,0.0001542765,0.0005316961,0.9662133,0.00003442892,0.02057304,0.0002088602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994561,0.001983983,0.0003324753,0.001439575,0.00007622418,0.0007560842,0.00002471103,0.00005467642,0.000771293],"genre_scores_gemma":[0.9823931,0.0003250641,0.0007859449,0.01629216,0.000110306,0.00001162776,0.00001958009,0.00004837032,0.00001383431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02425902,"threshold_uncertainty_score":0.9999926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0769790415024557,"score_gpt":0.3867153031926173,"score_spread":0.3097362616901616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}