{"id":"W3040208892","doi":"10.1016/j.immuni.2020.06.002","title":"Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells","year":2020,"lang":"en","type":"article","venue":"Immunity","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":347,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Guy's and St Thomas' NHS Foundation Trust; Comisión Nacional de Investigación Científica y Tecnológica; Biotechnology and Biological Sciences Research Council; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; National Centre for the Replacement Refinement and Reduction of Animals in Research; King’s College London; Cancer Research UK; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Rosetrees Trust; NIHR Exeter Clinical Research Facility; Centre National de la Recherche Scientifique; CNIB; National Institute for Health and Care Research; Institut Curie; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Worldwide Cancer Research","keywords":"Biology; Cell biology; CD11c; Priming (agriculture); CD8; Dendritic cell; Cytotoxic T cell; Immunology; CD163; Homing (biology); Antigen; In vitro; Macrophage; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013097,0.0001762248,0.0002030936,0.0002520543,0.0002046452,0.0003578163,0.00008697964,0.0002397339,0.003197335],"category_scores_gemma":[0.0001780914,0.00007315425,0.0002363354,0.0001862981,0.0001625503,0.0001006174,0.000114939,0.0004638008,0.0009306738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569523,"about_ca_system_score_gemma":0.0002054014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005443966,"about_ca_topic_score_gemma":0.0007119801,"domain_scores_codex":[0.9998977,0.00001162137,0.000007104518,0.00002663119,0.00001858245,0.00003821951],"domain_scores_gemma":[0.9998688,0.0000291336,0.00002092224,0.00002065676,0.00002746978,0.00003303543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093138,0.00001413804,0.000563343,0.00001728646,0.000001300183,0.00003216038,0.00001392633,0.00002844888,0.9979402,0.00005003774,0.00004210383,0.001187731],"study_design_scores_gemma":[0.00002412802,0.0003235519,0.02330133,0.00001296647,0.00001508662,0.0007307308,0.00009994124,0.001316008,0.9702615,0.0001935147,0.003713696,0.000007643094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908568,0.000704419,0.004124068,0.0001494054,0.00003736999,0.00006093997,0.001883891,0.00008994043,0.002093206],"genre_scores_gemma":[0.9911499,0.0003165285,0.003031926,0.00009252912,0.0000199193,0.00005967142,0.002627942,0.0000503788,0.002651234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003197335,"threshold_uncertainty_score":0.01069617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291211454557797,"score_gpt":0.2493791126785505,"score_spread":0.2164669981329725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}