{"id":"W3040271345","doi":"10.1101/2020.07.06.189993","title":"Proteomic profiling of mitochondrial-derived vesicles in brain reveals enrichment of respiratory complex sub-assemblies and small TIM chaperones","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; University of Oxford; Parkinson's Foundation; McGill University","keywords":"PINK1; Parkin; Biogenesis; Biology; Proteome; Mitophagy; Respiratory chain; Mitochondrion; Cell biology; Computational biology; Genetics; Gene; Autophagy; Parkinson's disease; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009594245,0.0004034021,0.0003359701,0.0008842845,0.0002101859,0.000348968,0.0001454246,0.0002067022,0.0005810499],"category_scores_gemma":[0.0001194735,0.0001069458,0.0003359506,0.0004248415,0.0001592523,0.0001862892,0.0003016168,0.0003417039,0.0002959833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001684371,"about_ca_system_score_gemma":0.0001498265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008514593,"about_ca_topic_score_gemma":0.0009972682,"domain_scores_codex":[0.9999372,0.000004349767,0.00000497066,0.0000162144,0.00001684867,0.0000204503],"domain_scores_gemma":[0.9999273,0.000008399396,0.00001772562,0.000003381236,0.00002161708,0.00002157204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000193221,0.00001195665,0.001878698,0.00008445296,0.00002783607,0.0001639149,0.0000321189,0.00002509271,0.9961058,0.00003270454,0.00005792942,0.001386228],"study_design_scores_gemma":[0.00001727145,0.0004793429,0.286087,0.00005771195,0.0002038556,0.003444042,0.0006539826,0.001986025,0.7027414,0.000336534,0.003960742,0.00003208033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907465,0.003905066,0.001928356,0.00007704667,0.00002987252,0.00003134397,0.002455628,0.00005538108,0.0007707967],"genre_scores_gemma":[0.9856892,0.003987089,0.003773465,0.0001138144,0.00002454454,0.00004950233,0.004062524,0.00004120531,0.002258762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008842845,"threshold_uncertainty_score":0.001943827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03032818719790139,"score_gpt":0.2428766558815923,"score_spread":0.2125484686836909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}