{"id":"W3040365468","doi":"10.1002/acn3.51103","title":"Neuronal RNA‐binding protein dysfunction in multiple sclerosis cortex","year":2020,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Cameco (Canada)","funders":"Saskatchewan Health Research Foundation; University of Saskatchewan","keywords":"Neurodegeneration; RNA-binding protein; Amyotrophic lateral sclerosis; Stress granule; Biology; RNA; Heterogeneous nuclear ribonucleoprotein; Neuroscience; Pathology; Cell biology; Medicine; Ribonucleoprotein; Messenger RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905756,0.0005265119,0.0003114823,0.0011055,0.0002975534,0.0003043436,0.0002337459,0.0001960607,0.001406527],"category_scores_gemma":[0.0006012812,0.0001463255,0.0001952531,0.0003508053,0.0004266853,0.0001787329,0.0003514334,0.0002254828,0.0002777777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004623697,"about_ca_system_score_gemma":0.0002931226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00238284,"about_ca_topic_score_gemma":0.002124066,"domain_scores_codex":[0.999832,0.00002882708,0.00001139128,0.00003993863,0.0000624181,0.0000253307],"domain_scores_gemma":[0.999706,0.0000313822,0.0001261437,0.00002079975,0.00006034632,0.00005540827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003640101,0.0003109786,0.2435663,0.0004869425,0.0006804437,0.01136662,0.00075998,0.001167952,0.7068439,0.0005199034,0.0008457428,0.02981119],"study_design_scores_gemma":[0.00005535168,0.0004888159,0.9583426,0.00002444445,0.0000940921,0.0160486,0.0002781823,0.001010636,0.02255151,0.0005565288,0.0005383778,0.00001086805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984912,0.0004471366,0.0003721216,0.00002593891,0.000002339243,0.000007914136,0.00008802396,0.00002461338,0.0005405846],"genre_scores_gemma":[0.9994038,0.0001493336,0.000182196,0.00001154766,0.000002222219,0.00000638845,0.00008764125,0.000002673755,0.0001541265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00238284,"threshold_uncertainty_score":0.004737914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3257427760972824,"score_gpt":0.395394493261586,"score_spread":0.06965171716430368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}