{"id":"W3040367438","doi":"10.1136/annrheumdis-2020-eular.3671","title":"OP0249 LONG-TERM EXTENSION RESULTS OF RISE-SSC, A RANDOMIZED TRIAL OF RIOCIGUAT IN PATIENTS WITH EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC)","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Bayer","keywords":"Riociguat; Medicine; Placebo; Clinical endpoint; Internal medicine; Randomized controlled trial; Pulmonary hypertension; Chronic thromboembolic pulmonary hypertension; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003181208,0.000168474,0.0006882487,0.00005068967,0.00002932418,0.000008248316,0.0004016518,0.0001014003,0.000007228549],"category_scores_gemma":[0.001612501,0.0001021573,0.0003194768,0.0001637399,0.0003742866,0.000005157948,0.0001828774,0.00007040113,0.000001581581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003792664,"about_ca_system_score_gemma":0.00008716188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000520168,"about_ca_topic_score_gemma":0.000003639072,"domain_scores_codex":[0.9978871,0.0005641236,0.0007061321,0.0002847719,0.0003523802,0.0002054469],"domain_scores_gemma":[0.9984449,0.000178008,0.0005108211,0.0005273338,0.0002354607,0.0001035284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9407573,0.001639716,0.03485906,0.000620615,0.0005104784,0.000006144166,0.0003032115,0.00006717431,0.01635929,0.00000661693,0.0002346688,0.004635738],"study_design_scores_gemma":[0.8092587,0.003578692,0.08808368,0.003225462,0.0003273226,0.000006984912,0.00008759935,0.0001390901,0.09485479,0.00007256318,0.000002944156,0.0003621606],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965911,0.00180134,0.00002136809,0.0001522876,0.00005070612,0.001204328,0.0001467566,0.000004321289,0.00002777335],"genre_scores_gemma":[0.9984548,0.00132232,0.00001244606,0.00003681135,0.00001840434,0.00003262268,0.00007357933,0.0000169506,0.00003205309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1314986,"threshold_uncertainty_score":0.4165854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02957464866230489,"score_gpt":0.2682321362984587,"score_spread":0.2386574876361538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}