{"id":"W3040367438","doi":"10.1136/annrheumdis-2020-eular.3671","title":"OP0249 LONG-TERM EXTENSION RESULTS OF RISE-SSC, A RANDOMIZED TRIAL OF RIOCIGUAT IN PATIENTS WITH EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC)","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Bayer","keywords":"Riociguat; Medicine; Placebo; Clinical endpoint; Internal medicine; Randomized controlled trial; Pulmonary hypertension; Chronic thromboembolic pulmonary hypertension; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001267097,0.00148652,0.003634211,0.0003158916,0.0003569557,0.001309093,0.0008717988,0.001492206,0.00686477],"category_scores_gemma":[0.001236116,0.0004865899,0.002183022,0.000339701,0.00099482,0.001180714,0.0004364392,0.004214167,0.001146892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004791622,"about_ca_system_score_gemma":0.0006653735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009781804,"about_ca_topic_score_gemma":0.002233804,"domain_scores_codex":[0.9993297,0.0003388869,0.00002953821,0.0001070389,0.00003762612,0.0001571887],"domain_scores_gemma":[0.9992775,0.0001944791,0.0001165069,0.00008230012,0.00004511898,0.0002841029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9790162,0.002490737,0.0007276279,0.0003940484,0.001262244,0.00005387606,0.00002555646,0.0002629331,0.001762474,0.0001290909,0.000615671,0.01325955],"study_design_scores_gemma":[0.951429,0.04308427,0.003228721,0.00003932403,0.001119125,0.00003099088,0.00003323675,0.0002906731,0.0002083881,0.0001293466,0.000391533,0.00001547344],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862853,0.006825309,0.0005212962,0.0008667089,0.0006138295,0.0007061176,0.0009592243,0.0001649035,0.003057309],"genre_scores_gemma":[0.9916961,0.001837023,0.000529371,0.00115141,0.0003774785,0.0007619486,0.001247982,0.00002690489,0.002371968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00686477,"threshold_uncertainty_score":0.02296489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02957464866230489,"score_gpt":0.2682321362984587,"score_spread":0.2386574876361538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}