{"id":"W3040450164","doi":"10.1158/1541-7786.mcr-20-0339","title":"Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Institutes of Health; Queen's University; Rosetrees Trust; National Cancer Institute; American Association for Cancer Research; Movember Foundation; Prostate Cancer Foundation; Prostate Cancer UK; Kreftforeningen; Norges Forskningsråd; Queen's University Belfast","keywords":"Synthetic lethality; Prostate cancer; Cancer research; Kinase; Biology; Cancer cell; Cyclin-dependent kinase; RNA polymerase II; Cancer; Molecular biology; Cell biology; Gene expression; Gene; Biochemistry; Cell cycle; DNA repair; Promoter; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004479057,0.0001777385,0.0001865196,0.0001448633,0.0001148186,0.00003928579,0.0002549422,0.0001552337,0.0003597994],"category_scores_gemma":[0.00009494214,0.0001729141,0.0001201073,0.0004719892,0.0001826937,0.000006793199,0.0001264666,0.0004313405,0.00003439731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007728999,"about_ca_system_score_gemma":0.0004406331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006101323,"about_ca_topic_score_gemma":0.000201258,"domain_scores_codex":[0.9971561,0.0003388679,0.0002714078,0.0006174555,0.001081548,0.0005345617],"domain_scores_gemma":[0.9988483,0.00001507797,0.00004609541,0.0003644123,0.000435212,0.000290885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001030392,0.00008860282,0.0001782782,0.0001423927,0.00006409279,0.00005058936,0.0002646708,0.002139374,0.9875054,0.00008474511,0.002476027,0.005975456],"study_design_scores_gemma":[0.001184499,0.0007532177,0.00009872333,0.00005459144,0.000007381749,8.701449e-7,0.0001322328,0.0001915593,0.987012,0.00003830729,0.0103531,0.0001734866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905598,0.001432955,0.0008361054,0.004433008,0.00005864341,0.0009871646,0.0002028894,0.0000150398,0.001474455],"genre_scores_gemma":[0.9967136,0.001406449,0.00006515792,0.0006873394,0.0001191998,0.000385174,0.00007992267,0.00004799534,0.0004951414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007877073,"threshold_uncertainty_score":0.7051234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04770161935424535,"score_gpt":0.3581240292420813,"score_spread":0.3104224098878359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}