{"id":"W3040519582","doi":"10.1182/blood.2020006374","title":"MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canada's Michael Smith Genome Sciences Centre; Institute for Research in Immunology and Cancer; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Haematopoiesis; Myeloid; Biology; Immunology; CD34; Cancer research; Population; Stem cell; Leukemia; Granulocyte macrophage colony-stimulating factor; Progenitor cell; Myeloid leukemia; Interleukin 3; Cytokine; T cell; Medicine; Cell biology; Immune system; Interleukin 21","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272176,0.0002329445,0.0001441782,0.0001326363,0.00009090099,0.0002862555,0.0001128044,0.0001549784,0.001128483],"category_scores_gemma":[0.0001508891,0.0001009486,0.0002400093,0.00009836159,0.00016084,0.0001238267,0.000234037,0.0003899195,0.0005201894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000274952,"about_ca_system_score_gemma":0.0002812473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006739622,"about_ca_topic_score_gemma":0.00117375,"domain_scores_codex":[0.9998733,0.00002483977,0.00001355745,0.00001822209,0.00003898382,0.00003105027],"domain_scores_gemma":[0.9998602,0.00003394489,0.0000316726,0.00002601499,0.00001207872,0.00003615842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001328158,0.00003232824,0.0002819105,0.00001276554,0.00000253013,0.00004124848,0.00001003138,0.00004362966,0.9979133,0.00008560278,0.0000324985,0.001411463],"study_design_scores_gemma":[0.00004227187,0.0004022011,0.008691874,0.000008636245,0.00001537263,0.0005807138,0.00001615175,0.001018974,0.9842669,0.00007186628,0.004881892,0.000003141281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993947,0.0009304963,0.002798202,0.0001241366,0.00002261252,0.00005706129,0.0005094621,0.0001247886,0.001486126],"genre_scores_gemma":[0.9953836,0.0003096344,0.002043032,0.00005615014,0.000008113872,0.00005141229,0.0007444285,0.00002219213,0.001381562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128483,"threshold_uncertainty_score":0.003775179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03386121464966615,"score_gpt":0.3071939903723446,"score_spread":0.2733327757226784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}