{"id":"W3040519582","doi":"10.1182/blood.2020006374","title":"MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canada's Michael Smith Genome Sciences Centre; Institute for Research in Immunology and Cancer; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Haematopoiesis; Myeloid; Biology; Immunology; CD34; Cancer research; Population; Stem cell; Leukemia; Granulocyte macrophage colony-stimulating factor; Progenitor cell; Myeloid leukemia; Interleukin 3; Cytokine; T cell; Medicine; Cell biology; Immune system; Interleukin 21","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003492181,0.0004186294,0.0007911909,0.0001802489,0.0002160492,0.0001116998,0.000501405,0.0003064424,0.0004679046],"category_scores_gemma":[0.0007376552,0.0003873654,0.0002519527,0.0006403635,0.0001596529,0.0002347538,0.0003844043,0.001104216,0.0007201609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004219359,"about_ca_system_score_gemma":0.0005900524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001846609,"about_ca_topic_score_gemma":0.00001922364,"domain_scores_codex":[0.9966604,0.0001225197,0.0006112805,0.0008221214,0.0008338472,0.0009498958],"domain_scores_gemma":[0.9978156,0.0001584581,0.0001671973,0.000724591,0.0002838311,0.0008503066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003930077,0.0002130031,0.002569825,0.0001724741,0.0007014791,0.002522645,0.002384993,0.000002868428,0.9716133,0.0002169314,0.0130993,0.006110136],"study_design_scores_gemma":[0.04942518,0.005318861,0.01862978,0.0007997838,0.002817337,0.001195516,0.001461592,0.001750648,0.8645723,0.0002571725,0.05211687,0.001654907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980364,0.0002483575,0.00006923806,0.004733589,0.0001008327,0.0009664279,0.00005076143,0.0005008348,0.01296599],"genre_scores_gemma":[0.9923494,0.0000848135,0.001136129,0.002956219,0.001208516,0.000075247,0.0001227834,0.0001297728,0.001937107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.107041,"threshold_uncertainty_score":0.9998578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03386121464966615,"score_gpt":0.3071939903723446,"score_spread":0.2733327757226784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}