{"id":"W3040633579","doi":"10.1016/j.addr.2020.06.026","title":"Lipid nanoparticle technology for therapeutic gene regulation in the liver","year":2020,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":362,"is_retracted":false,"has_abstract":false,"ca_institutions":"Evonik (Canada); BC Children's Hospital; NanoMedicines Innovation Network; University of British Columbia","funders":"Networks of Centres of Excellence of Canada; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Gene silencing; Genetic enhancement; Gene; Nucleic acid; Medicine; Genome editing; Translation (biology); RNA interference; Biology; Gene delivery; Disease; Bioinformatics; Computational biology; Biotechnology; Cancer research; Genetics; Genome; RNA; Messenger RNA; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004500609,0.001011753,0.001248932,0.00139449,0.0002024898,0.0007797256,0.0006850776,0.0009790788,0.002971787],"category_scores_gemma":[0.0002860842,0.0003148513,0.0004126968,0.001355337,0.0004282474,0.0009642788,0.0006234932,0.001606937,0.002580083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006628784,"about_ca_system_score_gemma":0.0006291185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009568243,"about_ca_topic_score_gemma":0.001625963,"domain_scores_codex":[0.999866,0.00001955667,0.0000101663,0.00002224976,0.00006328353,0.00001880277],"domain_scores_gemma":[0.9998983,0.00004997801,0.00001511176,0.000003907814,0.00002262255,0.00001003964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001050876,0.00009736795,0.00005146927,0.01079378,0.00006186652,0.000241921,0.00003629309,0.000594873,0.02426239,0.008216573,0.02670178,0.9288365],"study_design_scores_gemma":[0.00003320249,0.0001775179,0.0002928943,0.001368979,0.00007167437,0.0009417223,0.00002307409,0.0002780485,0.006246035,0.002260576,0.9882776,0.00002867495],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001753937,0.9971956,0.0006660896,0.0001538342,0.000281633,0.000006467643,0.00001283948,0.00001599495,0.001492177],"genre_scores_gemma":[0.001181122,0.995774,0.0006183265,0.0001551818,0.0001447882,0.00001238258,0.00003132785,0.000003931175,0.002079047],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002971787,"threshold_uncertainty_score":0.009941638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0423307275526725,"score_gpt":0.3196818613254067,"score_spread":0.2773511337727342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}