{"id":"W3040668037","doi":"10.1101/2020.07.06.186809","title":"Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec; Canadian Institutes of Health Research; Royal Society; Royal Society of Canada; McGill University","keywords":"Postsynaptic potential; Excitatory postsynaptic potential; Neurodegeneration; Neurotransmission; Hippocampal formation; Dendritic spine; Neuroscience; Inhibitory postsynaptic potential; Biology; Synaptic vesicle; Cell biology; Chemistry; Pathology; Medicine; Biochemistry; Vesicle; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008397418,0.0003832268,0.0001909167,0.0001747173,0.00009631608,0.0001779334,0.0001484868,0.0002115523,0.0009711893],"category_scores_gemma":[0.0001010433,0.00009827186,0.0001516859,0.00008457957,0.0001778755,0.0001575865,0.0002074469,0.000285574,0.0002906811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386893,"about_ca_system_score_gemma":0.0001253876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007423037,"about_ca_topic_score_gemma":0.001144953,"domain_scores_codex":[0.9999424,0.000005360971,0.00001085584,0.00001098768,0.00001841649,0.00001206006],"domain_scores_gemma":[0.9999202,0.00001252375,0.00002295427,0.000009725773,0.00001280464,0.00002173337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005558484,0.00001091436,0.001072468,0.0000373623,0.000009648711,0.0002439462,0.0000119917,0.00002627871,0.9975414,0.00004164399,0.00003696944,0.0009118887],"study_design_scores_gemma":[0.00001778708,0.000495536,0.09184321,0.00003784382,0.00005082554,0.003761613,0.00009804246,0.0004106135,0.9004042,0.0002076093,0.00266574,0.00000689368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958267,0.001665029,0.0009087893,0.00003426694,0.00001327472,0.000009317346,0.000520505,0.00005724552,0.0009648803],"genre_scores_gemma":[0.9973436,0.0008179475,0.0004829422,0.00002320675,0.000002772338,0.000009151784,0.0003604659,0.000007175772,0.0009527792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009711893,"threshold_uncertainty_score":0.00324899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01882669489649745,"score_gpt":0.2555989655269632,"score_spread":0.2367722706304657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}