{"id":"W3040693067","doi":"10.14814/phy2.14481","title":"BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL‐induced DNA damage and endothelial apoptosis","year":2020,"lang":"en","type":"article","venue":"Physiological Reports","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Western University","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"DNA damage; Endothelial dysfunction; Cancer research; Apoptosis; Biology; DNA repair; Gene; DNA; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261843,0.0002556308,0.0003921786,0.0002812146,0.00009236659,0.0002406966,0.0001174281,0.0002944517,0.0008980749],"category_scores_gemma":[0.0001259926,0.0001707534,0.0002154511,0.0001720799,0.0001146637,0.00009539154,0.0001774397,0.0004378654,0.0001438512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565509,"about_ca_system_score_gemma":0.0001172529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004515075,"about_ca_topic_score_gemma":0.0006454152,"domain_scores_codex":[0.9998649,0.00002694101,0.00001277244,0.00002629347,0.0000340615,0.00003495625],"domain_scores_gemma":[0.9998946,0.00001027875,0.00003848739,0.000009885274,0.00001051475,0.00003618357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000683323,0.00009670921,0.002415094,0.00005267153,0.00002306253,0.0005882441,0.00003173037,0.00003120458,0.9939751,0.00004682027,0.0001036414,0.001952346],"study_design_scores_gemma":[0.0001817401,0.002524575,0.1949836,0.00004337503,0.0002155611,0.006858877,0.0002996127,0.002262555,0.7848949,0.0003226037,0.007388591,0.00002405637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977719,0.001084634,0.0004537498,0.00007545768,0.00001819571,0.0000105991,0.0001128458,0.00003660976,0.0004359226],"genre_scores_gemma":[0.9969548,0.0008843975,0.0003661418,0.00009550677,0.00001122994,0.00002068647,0.0002134314,0.00000796635,0.00144592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008980749,"threshold_uncertainty_score":0.003004313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02818214915306023,"score_gpt":0.2823461621880475,"score_spread":0.2541640130349873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}