{"id":"W3040748390","doi":"10.1038/s41398-020-00918-y","title":"Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice","year":2020,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"ADAM10; Capsaicin; Medicine; Cognitive decline; Neuroinflammation; Dementia; Amyloid precursor protein; Neurodegeneration; Alzheimer's disease; Population; Amyloid beta; Disease; Pharmacology; Internal medicine; Metalloproteinase; Disintegrin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009277755,0.0001760891,0.0002163955,0.0001004115,0.00009598593,0.00002198892,0.00002918633,0.00007987622,0.00007270876],"category_scores_gemma":[0.00003059043,0.0001660308,0.00004108507,0.0001530918,0.0001569659,0.0001377089,0.000009970287,0.0001713751,0.00003730543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007528919,"about_ca_system_score_gemma":0.0002321205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001956272,"about_ca_topic_score_gemma":0.00006484584,"domain_scores_codex":[0.9987793,0.0001119116,0.0002386077,0.0004221279,0.0002363288,0.0002117371],"domain_scores_gemma":[0.9993392,0.0001059566,0.00004943104,0.00006295046,0.00007921033,0.0003632884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002994001,0.0004295905,0.9820707,0.0001640131,0.00152227,0.0001284977,0.0007364075,0.00002375831,0.003132226,0.001030896,0.0007814873,0.006986111],"study_design_scores_gemma":[0.005050906,0.0003497853,0.9886524,0.0001244955,0.001024419,0.00005158463,0.0001383833,0.003346346,0.0003863577,0.0006314142,0.00002827584,0.0002156321],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9107977,0.06288617,0.00005871435,0.02531393,0.00006898939,0.0005981282,0.0001623509,0.00003360833,0.00008039268],"genre_scores_gemma":[0.9963456,0.0004453827,0.0005266286,0.00144426,0.0002046498,0.00002805756,0.0009796113,0.00002082677,0.000004947852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08554792,"threshold_uncertainty_score":0.6770541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06684976473536766,"score_gpt":0.3347698130077968,"score_spread":0.2679200482724291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}