{"id":"W3040782867","doi":"10.1038/s41375-020-0979-6","title":"Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide","year":2020,"lang":"en","type":"letter","venue":"Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"Rosetrees Trust; National Cancer Institute; Medical Research Council; National Institute for Health and Care Research; Cancer Research UK","keywords":"Pomalidomide; Myelofibrosis; Myeloproliferative neoplasm; Medicine; Polycythemia vera; Hematology; Spliceosome; Neoplasm; Myeloproliferative Disorders; Internal medicine; Pathology; Bone marrow; Biology; Genetics; Multiple myeloma; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003247611,0.0004196695,0.0004887876,0.0006800878,0.0006714151,0.0006091557,0.0003877448,0.003002516,0.002296519],"category_scores_gemma":[0.003176114,0.0002394128,0.0003903199,0.0007185017,0.0005773852,0.0005526404,0.0002129513,0.001454048,0.0006978083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004093403,"about_ca_system_score_gemma":0.0003661716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001927356,"about_ca_topic_score_gemma":0.002757268,"domain_scores_codex":[0.9995654,0.00009311146,0.00007189965,0.00007223119,0.000111508,0.00008579105],"domain_scores_gemma":[0.9986274,0.0005920489,0.0003260152,0.0000719003,0.0001567072,0.0002259609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007594993,0.0002646057,0.523043,0.0001242751,0.00008876563,0.4004316,0.0005823466,0.0002782771,0.005731586,0.001630718,0.03946237,0.02760294],"study_design_scores_gemma":[0.00008643732,0.0004655104,0.3101749,0.0001073823,0.0001076467,0.6573323,0.0006996891,0.00137708,0.001312806,0.002208336,0.02607682,0.00005111337],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8298105,0.005410607,0.00221131,0.1167418,0.00355431,0.00008684702,0.001124403,0.0002329868,0.04082717],"genre_scores_gemma":[0.9544464,0.001889091,0.001148425,0.02953989,0.005831665,0.00002994076,0.0003033412,0.00004225369,0.006768977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003002516,"threshold_uncertainty_score":0.007682562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197213321417305,"score_gpt":0.2384477853790693,"score_spread":0.2264756521648963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}