{"id":"W3040803176","doi":"10.1038/s41467-020-17154-z","title":"A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"CIHR Skin Research Training Centre; National Institute of Allergy and Infectious Diseases; Global Health Innovative Technology Fund; Canadian Institutes of Health Research; National Institutes of Health; Government of Canada","keywords":"CRISPR; Leishmania; Biology; Genome editing; Attenuated vaccine; Immune system; Virology; Leishmania major; Cutaneous leishmaniasis; Vaccination; Leishmaniasis; Gene; Vector (molecular biology); Strain (injury); Microbiology; Parasite hosting; Immunology; Genetics; Virulence; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438943,0.0004950995,0.0002887341,0.0002202623,0.0001068571,0.0003198357,0.0003233665,0.000516957,0.001857282],"category_scores_gemma":[0.00008919917,0.0001429558,0.0002997758,0.0000974514,0.0001914246,0.0001847005,0.0002656352,0.0007786133,0.0004743187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002092158,"about_ca_system_score_gemma":0.0001639717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264551,"about_ca_topic_score_gemma":0.00039583,"domain_scores_codex":[0.9998654,0.00001752499,0.00001173101,0.00003763627,0.00003884643,0.00002887983],"domain_scores_gemma":[0.9999126,0.00001152478,0.00003141467,0.00001123689,0.000009426651,0.00002373279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005341632,0.0000410662,0.00005431575,0.00002972099,0.000004546093,0.00003194794,0.000005360598,0.00006663872,0.9982426,0.00007238057,0.0001039262,0.001294084],"study_design_scores_gemma":[0.00004725881,0.001140045,0.0009875551,0.000008601341,0.00002719802,0.0004698258,0.00001466156,0.001198028,0.9891482,0.00004449104,0.006903226,0.00001081048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491599,0.001420794,0.04115031,0.000560286,0.0003295117,0.00036835,0.001352785,0.001054733,0.004603373],"genre_scores_gemma":[0.975668,0.0005736883,0.01272209,0.0001886296,0.00002796466,0.0001814655,0.001191544,0.00006801146,0.009378719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001857282,"threshold_uncertainty_score":0.006213248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06198576126498123,"score_gpt":0.3354753086962541,"score_spread":0.2734895474312729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}