{"id":"W3040906182","doi":"10.1016/j.mib.2020.06.002","title":"Beyond the CRISPR-Cas safeguard: PICI-encoded innate immune systems protect bacteria from bacteriophage predation","year":2020,"lang":"en","type":"review","venue":"Current Opinion in Microbiology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Wolfson Foundation; Medical Research Council; Royal Society; Medical Research Council Canada; Wellcome Trust; Fundación Ramón Areces","keywords":"Biology; Bacteriophage; CRISPR; Virulence; Innate immune system; Bacteria; Microbiology; Immune system; Genetics; Gene; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054385,0.0008378704,0.001321011,0.0009020546,0.0001848202,0.001491746,0.0009346374,0.001319603,0.003422589],"category_scores_gemma":[0.00058659,0.0001957111,0.0004675853,0.0009016345,0.0006035566,0.001290261,0.0007157271,0.002405251,0.001912527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006879957,"about_ca_system_score_gemma":0.001183906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007289852,"about_ca_topic_score_gemma":0.001171219,"domain_scores_codex":[0.999792,0.00002887254,0.00001579247,0.00004000165,0.00009079494,0.00003242495],"domain_scores_gemma":[0.999687,0.0001387455,0.0000514927,0.00000994923,0.00006311587,0.00004973079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001175987,0.00003240704,0.000134328,0.01253084,0.00009026429,0.0001241779,0.00003729565,0.0003469989,0.01137695,0.006798853,0.02700774,0.9414026],"study_design_scores_gemma":[0.00001796892,0.00008285402,0.0006523681,0.001729973,0.00009051222,0.0005501159,0.00003756387,0.0001948579,0.003036397,0.003202265,0.9903789,0.00002625574],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001835796,0.9971512,0.0004748482,0.000497569,0.000395498,0.00000317065,0.00002566568,0.00002246044,0.001245917],"genre_scores_gemma":[0.002177392,0.9951655,0.0004515444,0.0005291133,0.0003262766,0.000006076942,0.00006647203,0.000004936186,0.001272691],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003422589,"threshold_uncertainty_score":0.01144969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04167131761088139,"score_gpt":0.3289992563377653,"score_spread":0.2873279387268839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}