{"id":"W3040981623","doi":"10.3390/antib9030032","title":"Improving Receptor-Mediated Intracellular Access and Accumulation of Antibody Therapeutics—The Tale of HER2","year":2020,"lang":"en","type":"review","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Internalization; Intracellular; Antibody-drug conjugate; Antibody; Drug; Cancer research; Medicine; Receptor; Monoclonal antibody; Biology; Pharmacology; Immunology; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004223988,0.0005306557,0.0007547627,0.001246298,0.0001927631,0.0007519198,0.0005271318,0.0007098726,0.00296102],"category_scores_gemma":[0.0003318204,0.00021923,0.0004509479,0.0009575087,0.0002800465,0.001094295,0.0004739254,0.001371164,0.001670233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004860513,"about_ca_system_score_gemma":0.0007154271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000717949,"about_ca_topic_score_gemma":0.001263443,"domain_scores_codex":[0.9998475,0.00003106221,0.00001220548,0.00002132301,0.00006377723,0.00002411917],"domain_scores_gemma":[0.9999039,0.00003666018,0.00001407809,0.00000435914,0.00003268713,0.000008373471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007247539,0.0000804495,0.000143971,0.02169285,0.00009835169,0.0002429256,0.00009816737,0.0006906819,0.01529313,0.01811512,0.02629767,0.9171743],"study_design_scores_gemma":[0.000009036415,0.0001083169,0.0003102851,0.001391656,0.00004952319,0.0006566463,0.00003781392,0.0001464511,0.002815418,0.002079544,0.9923839,0.00001137738],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005698385,0.9946378,0.0005652008,0.0004893061,0.0002568696,0.00001177721,0.00003190978,0.00001662742,0.003420722],"genre_scores_gemma":[0.002502015,0.9948502,0.0004554797,0.0002643251,0.00007600346,0.00001222351,0.00003442395,0.000002250813,0.001803042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00296102,"threshold_uncertainty_score":0.009905577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1416993498253571,"score_gpt":0.4447093743096557,"score_spread":0.3030100244842986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}