{"id":"W3041012431","doi":"10.1111/epi.16592","title":"Functional and behavioral signatures of Kv7 activator drug subtypes","year":2020,"lang":"en","type":"article","venue":"Epilepsia","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Zebrafish; Activator (genetics); Neuroscience; In vivo; Epilepsy; Anticonvulsant; Pharmacology; Drug; Biology; Biochemistry; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000331001,0.00006250414,0.00006600574,0.00001441529,0.00003172334,0.000005806416,0.00003073187,0.00006635261,0.0001220611],"category_scores_gemma":[0.00002146125,0.00005786322,0.00003536408,0.00004214128,0.00003958632,0.000003521174,0.00002852284,0.00004678005,0.000005118243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002395353,"about_ca_system_score_gemma":0.00001826542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003488848,"about_ca_topic_score_gemma":0.000001270218,"domain_scores_codex":[0.9996102,0.00001848249,0.00008623335,0.0001476485,0.00007430886,0.00006307843],"domain_scores_gemma":[0.9997978,0.000004835206,0.00004129374,0.00006049516,0.0000415638,0.00005404035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003718264,0.00005116994,0.009532342,0.00001954603,0.00002585492,8.012896e-7,0.0001547289,0.0001812004,0.9350762,0.0005139985,0.05183481,0.002237509],"study_design_scores_gemma":[0.0009133815,0.0004266302,0.1225771,0.000007661225,0.00002734343,0.00000491401,0.0002390597,0.0006752262,0.7387623,0.00007990719,0.1360597,0.0002267563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973171,0.0002251927,0.001136322,0.0007573681,0.0002123797,0.00006083206,0.00001202078,0.00001013979,0.0002686965],"genre_scores_gemma":[0.9985734,0.00001976861,0.0001286232,0.0003559174,0.0003878523,0.000003552619,0.0001019498,0.000007651699,0.0004213509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1963139,"threshold_uncertainty_score":0.2359594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963018590338438,"score_gpt":0.2490212138753793,"score_spread":0.229391027971995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}