{"id":"W3041012431","doi":"10.1111/epi.16592","title":"Functional and behavioral signatures of Kv7 activator drug subtypes","year":2020,"lang":"en","type":"article","venue":"Epilepsia","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Zebrafish; Activator (genetics); Neuroscience; In vivo; Epilepsy; Anticonvulsant; Pharmacology; Drug; Biology; Biochemistry; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770482,0.0003496179,0.0003468967,0.0003951258,0.0001427526,0.0003579161,0.0001954569,0.0003285338,0.001416721],"category_scores_gemma":[0.0003556435,0.0001235677,0.0002412386,0.0001387566,0.0002048766,0.0002147126,0.0001591964,0.0003595073,0.0003075477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004016696,"about_ca_system_score_gemma":0.0002136841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015843,"about_ca_topic_score_gemma":0.001292421,"domain_scores_codex":[0.9997957,0.00003265919,0.00002874799,0.00004043293,0.00006071195,0.00004185796],"domain_scores_gemma":[0.9997934,0.00003772344,0.00005353176,0.0000171492,0.00006231333,0.00003591804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001696488,0.00002215374,0.0005659374,0.00003306843,0.000007912377,0.00002206409,0.00000975391,0.00004742774,0.9975488,0.00003552401,0.00004836405,0.001489264],"study_design_scores_gemma":[0.00003701944,0.002182595,0.04156836,0.00001671637,0.00007948293,0.0006023097,0.00009139936,0.002049716,0.9517373,0.0000795829,0.001538725,0.0000167847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952477,0.0008823608,0.001088254,0.00007569032,0.00001293069,0.00006511424,0.0007462698,0.00007827044,0.001803397],"genre_scores_gemma":[0.9960921,0.0005220657,0.001197264,0.0000957345,0.000005015177,0.00006253521,0.0007463483,0.00001858574,0.00126039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416721,"threshold_uncertainty_score":0.004739404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963018590338438,"score_gpt":0.2490212138753793,"score_spread":0.229391027971995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}