{"id":"W3041065352","doi":"10.3390/biom10071014","title":"The Addition of a Synthetic LPS-Targeting Domain Improves Serum Stability While Maintaining Antimicrobial, Antibiofilm, and Cell Stimulating Properties of an Antimicrobial Peptide","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Antimicrobial; Antimicrobial peptides; Microbiology; Biofilm; Peptide; Antibiotics; Staphylococcus aureus; Chemistry; Escherichia coli; Trypsin; Bacteria; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004319613,0.0002964743,0.0004813595,0.00006017848,0.0004829856,0.00006343148,0.0002863909,0.0001816641,0.00004032037],"category_scores_gemma":[0.0001414268,0.0002251337,0.0001377608,0.0001557567,0.001459981,0.0002437961,0.0002569433,0.0002276118,0.000006794595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001744732,"about_ca_system_score_gemma":0.00007855867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002083613,"about_ca_topic_score_gemma":0.00002563559,"domain_scores_codex":[0.9979917,0.0003639291,0.0006533022,0.0004712022,0.00005912109,0.0004607847],"domain_scores_gemma":[0.998951,0.0001480572,0.000468462,0.0002685294,0.0001189983,0.00004498778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003805484,0.000125291,0.0004433056,0.0003293414,0.00007158578,0.000002604813,0.001738828,0.00001380141,0.9953232,0.0001378832,0.0003700308,0.001063551],"study_design_scores_gemma":[0.00073004,0.0003987433,0.0003752908,0.0002166747,0.00005094441,0.00001799835,0.005420561,0.0001278076,0.9921426,0.00002538504,0.0002293791,0.0002645941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973207,0.0006474947,0.0002819489,0.0006680415,0.0001224993,0.0003894258,0.0003957581,0.00006415678,0.000109947],"genre_scores_gemma":[0.9980438,0.00008267003,0.00154093,0.0001368409,0.00004431194,0.000003526919,0.00009284766,0.00003616563,0.00001889637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003681734,"threshold_uncertainty_score":0.9180684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574815918318906,"score_gpt":0.206502707162038,"score_spread":0.190754547978849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}