{"id":"W3041065352","doi":"10.3390/biom10071014","title":"The Addition of a Synthetic LPS-Targeting Domain Improves Serum Stability While Maintaining Antimicrobial, Antibiofilm, and Cell Stimulating Properties of an Antimicrobial Peptide","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Antimicrobial; Antimicrobial peptides; Microbiology; Biofilm; Peptide; Antibiotics; Staphylococcus aureus; Chemistry; Escherichia coli; Trypsin; Bacteria; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400002,0.0003536473,0.0001214293,0.0001463216,0.00006456837,0.0001778506,0.0001354442,0.0002491159,0.0004794578],"category_scores_gemma":[0.000167572,0.00007001257,0.0001508456,0.0001071122,0.0001268182,0.0001876438,0.0001906233,0.0003068457,0.0001554828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001109926,"about_ca_system_score_gemma":0.0001140039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001221683,"about_ca_topic_score_gemma":0.0001398027,"domain_scores_codex":[0.9998914,0.00002909966,0.00001159559,0.00001785964,0.00002902045,0.00002109268],"domain_scores_gemma":[0.9998789,0.0000182617,0.00005773574,0.000008004909,0.00001448841,0.00002257403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005022132,0.00001469982,0.00006300552,0.0000233859,0.000001667525,0.00001913484,0.00000352328,0.00005195574,0.9990143,0.00001625955,0.000007330432,0.0007345489],"study_design_scores_gemma":[0.000009294543,0.0004197331,0.00118548,0.000004875743,0.000009029514,0.0001503131,0.00000836735,0.0004092385,0.9967279,0.00001253851,0.001059324,0.000003819853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962309,0.001096262,0.002103998,0.00004777907,0.00001657586,0.00001141794,0.00006535584,0.00001924462,0.0004083856],"genre_scores_gemma":[0.995337,0.0005629808,0.00324578,0.00003985353,0.000008794314,0.00001470072,0.0001736579,0.000007631726,0.0006094898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004794578,"threshold_uncertainty_score":0.001603961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574815918318906,"score_gpt":0.206502707162038,"score_spread":0.190754547978849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}