{"id":"W3041098034","doi":"10.1038/s41598-020-68226-5","title":"Optimized ex vivo stimulation identifies multi-functional HBV-specific T cells in a majority of chronic hepatitis B patients","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"J.P. Bickell Foundation","keywords":"Ex vivo; ELISPOT; In vivo; Immunology; T cell; Medicine; Hepatitis B; Peripheral blood mononuclear cell; Antigen; Virology; Biology; In vitro; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006501848,0.0002194856,0.0005521417,0.0002723582,0.0001680536,0.00007510062,0.00008248092,0.00009946302,0.0009444382],"category_scores_gemma":[0.0005010636,0.0002128173,0.0001675675,0.0008191208,0.0003327476,0.0002669916,0.0001367988,0.0001911462,0.00007982479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002960464,"about_ca_system_score_gemma":0.0002503196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101772,"about_ca_topic_score_gemma":0.001073435,"domain_scores_codex":[0.9965796,0.00008029913,0.001124087,0.0008703708,0.001000272,0.0003453187],"domain_scores_gemma":[0.9981565,0.00006841581,0.0004705546,0.0005318927,0.0005918166,0.0001807729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001327594,0.0006464533,0.9095499,0.0002585482,0.00005757298,0.0003289998,0.001415378,0.002333081,0.05709776,0.000009358403,0.02737689,0.0007932926],"study_design_scores_gemma":[0.004026523,0.0002975548,0.8881929,0.0003287641,0.00008952431,0.00002150614,0.000062926,0.01459889,0.0785023,0.0002167906,0.01325496,0.0004073593],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907418,0.0003326815,0.002011546,0.0001705962,0.005290034,0.001023728,0.00002654268,0.00007542148,0.0003276437],"genre_scores_gemma":[0.9962583,0.00008705916,0.002293575,0.00004720815,0.000139785,0.0000362439,0.0001796637,0.00002538135,0.0009327787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02140455,"threshold_uncertainty_score":0.9999688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03491017658142746,"score_gpt":0.2655835431515446,"score_spread":0.2306733665701172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}