{"id":"W3041098034","doi":"10.1038/s41598-020-68226-5","title":"Optimized ex vivo stimulation identifies multi-functional HBV-specific T cells in a majority of chronic hepatitis B patients","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"J.P. Bickell Foundation","keywords":"Ex vivo; ELISPOT; In vivo; Immunology; T cell; Medicine; Hepatitis B; Peripheral blood mononuclear cell; Antigen; Virology; Biology; In vitro; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002580246,0.0002664789,0.0002703227,0.0001479454,0.00009659422,0.0002961547,0.00006952701,0.000275687,0.001422201],"category_scores_gemma":[0.0002994439,0.000124555,0.0001069307,0.0001020679,0.0001291395,0.0001320157,0.000133538,0.0003054086,0.0003921038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000641714,"about_ca_system_score_gemma":0.00006121889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001014131,"about_ca_topic_score_gemma":0.0001165766,"domain_scores_codex":[0.999828,0.00006426552,0.0000183835,0.00003749884,0.00002158826,0.0000302647],"domain_scores_gemma":[0.9998791,0.00004318319,0.00001613157,0.00001540361,0.00001585158,0.00003033002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009004347,0.0001476588,0.02031957,0.00005964487,0.000008837629,0.0001733969,0.00008929163,0.0001681561,0.9715413,0.00003205024,0.00009916,0.006460522],"study_design_scores_gemma":[0.0002274109,0.01091928,0.3641821,0.00004217646,0.0001222201,0.006874768,0.0003847067,0.004253065,0.6091776,0.0002135646,0.003580098,0.0000229683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982907,0.0002603723,0.0008809572,0.00001874618,0.000006574914,0.00001950725,0.00009573568,0.00001325646,0.0004141269],"genre_scores_gemma":[0.9984636,0.00007619511,0.0008377079,0.00004112982,0.00001035974,0.00002671154,0.000240163,0.000005132574,0.0002989501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422201,"threshold_uncertainty_score":0.004757702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03491017658142746,"score_gpt":0.2655835431515446,"score_spread":0.2306733665701172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}