{"id":"W3041140672","doi":"10.1093/abbs/gmaa067","title":"Isoliquiritigenin inhibits TGF-&amp;lt;roman&amp;gt;&amp;beta;&amp;lt;/roman&amp;gt;1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells","year":2020,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Ginseng Biological Effects and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Hubei University of Medicine; National Natural Science Foundation of China","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Wortmannin; LY294002; Autophagy; Chemistry; Molecular biology; Cell biology; Signal transduction; Cancer research; Biology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0004209861,0.001281911,0.001299693,0.000141372,0.0005058167,0.0002275567,0.001379581,0.001169237,0.0002230075],"category_scores_gemma":[0.0005138991,0.001187243,0.0008101467,0.001138844,0.0005225282,0.00007200734,0.0009976098,0.0008799219,0.000748491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009428347,"about_ca_system_score_gemma":0.0002922881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001246782,"about_ca_topic_score_gemma":0.0002273904,"domain_scores_codex":[0.9932707,0.0006108814,0.001472395,0.002560808,0.0005835831,0.001501612],"domain_scores_gemma":[0.9958747,0.0004221696,0.0008169587,0.001989656,0.0002424648,0.0006540237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003130316,0.0008779988,0.00001953718,0.0001085805,0.0002168485,0.00000424026,0.0005158231,0.00002913855,0.9887825,0.000303221,0.006968782,0.001860267],"study_design_scores_gemma":[0.001054741,0.0005692042,0.0007156454,0.0001048711,0.00006981551,0.00001516023,0.00001840144,0.00002659513,0.743229,0.0001928125,0.2528153,0.001188467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890079,0.000509606,0.001076464,0.005871004,0.0002617289,0.001336449,0.0005804034,0.0002843442,0.001072109],"genre_scores_gemma":[0.978649,0.0004102806,0.01242657,0.003921999,0.001042155,0.000300018,0.002502139,0.0002155396,0.0005323511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2458465,"threshold_uncertainty_score":0.9999933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03752071578205924,"score_gpt":0.2863683675804311,"score_spread":0.2488476517983719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}