{"id":"W3041140672","doi":"10.1093/abbs/gmaa067","title":"Isoliquiritigenin inhibits TGF-&amp;lt;roman&amp;gt;&amp;beta;&amp;lt;/roman&amp;gt;1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells","year":2020,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Ginseng Biological Effects and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Hubei University of Medicine; National Natural Science Foundation of China","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Wortmannin; LY294002; Autophagy; Chemistry; Molecular biology; Cell biology; Signal transduction; Cancer research; Biology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007727584,0.0003169384,0.0002615719,0.0001778104,0.00008992168,0.000111092,0.0001104852,0.0001497132,0.0008889561],"category_scores_gemma":[0.00005670731,0.00007119373,0.0001886227,0.0001285943,0.0001456442,0.0001346575,0.00009255333,0.0004114502,0.0003022988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001976894,"about_ca_system_score_gemma":0.0001823306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005712008,"about_ca_topic_score_gemma":0.001093426,"domain_scores_codex":[0.999959,0.000006847314,0.000005639434,0.000006518001,0.000009321311,0.00001268505],"domain_scores_gemma":[0.9999707,0.000004503381,0.00000960734,0.00000225422,0.000003228163,0.000009655673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002979117,0.00007218972,0.000122493,0.00007846117,0.000005674729,0.00005217756,0.0000140221,0.00005466493,0.9974674,0.00003108562,0.00008568972,0.001718279],"study_design_scores_gemma":[0.0001078432,0.001344601,0.006579482,0.00001015897,0.00002929801,0.0003201618,0.00003673381,0.0009647218,0.9873465,0.00003747737,0.003217916,0.000005183473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935847,0.002208779,0.00113683,0.0001246424,0.00003720651,0.00003332385,0.0004002241,0.0001046552,0.002369742],"genre_scores_gemma":[0.9929224,0.001421793,0.001779836,0.0001012056,0.00002386193,0.00004884755,0.0009117055,0.0000216898,0.002768549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008889561,"threshold_uncertainty_score":0.002973795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03752071578205924,"score_gpt":0.2863683675804311,"score_spread":0.2488476517983719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}