{"id":"W3041151012","doi":"10.1101/2020.07.10.197533","title":"Abnormal craniofacial and spinal bone development with <i>col2a1</i> a depletion in a zebrafish model of CHARGE syndrome","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Congenital Ear and Nasal Anomalies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; McGill University; Montreal Children's Hospital; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; ALS Society of Canada; Shriners Hospitals for Children; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Zebrafish; Craniofacial; CHARGE syndrome; Craniofacial abnormality; Osteoblast; Anatomy; Biology; Scoliosis; Osteopenia; Cartilage; Bone mineral; Pathology; Cell biology; Medicine; Endocrinology; Gene; Genetics; Osteoporosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172851,0.0008105622,0.0002905431,0.001244738,0.0004833404,0.0003177838,0.0004748187,0.0009217607,0.003871535],"category_scores_gemma":[0.00010904,0.0003681777,0.0004068195,0.0002462897,0.0008113783,0.0002745193,0.0004919558,0.001031454,0.000693088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007545725,"about_ca_system_score_gemma":0.0005766294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005924924,"about_ca_topic_score_gemma":0.01092751,"domain_scores_codex":[0.9997187,0.00002837678,0.00002695072,0.00007588295,0.0000997138,0.00005032224],"domain_scores_gemma":[0.9997873,0.00002522728,0.00007369318,0.00001615377,0.00001927665,0.00007838226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006047364,0.00002200471,0.0001614916,0.00002883992,0.000005169086,0.0002443155,0.0000227657,0.00007974813,0.9986093,0.0001816239,0.000104634,0.0004796193],"study_design_scores_gemma":[0.0001318671,0.0007921899,0.01568351,0.00005119537,0.00007157436,0.00193026,0.000223921,0.003509437,0.9708499,0.0002516049,0.006468765,0.00003591123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804028,0.001060606,0.008728106,0.0005691909,0.0001138985,0.0001809925,0.003712531,0.0004766693,0.00475511],"genre_scores_gemma":[0.9747247,0.0008557733,0.008920263,0.0002111326,0.00001419246,0.0002432192,0.001553041,0.0002019468,0.01327581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005924924,"threshold_uncertainty_score":0.01295155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697264973043684,"score_gpt":0.2091593601692364,"score_spread":0.1921867104387995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}