{"id":"W3041194062","doi":"10.1002/art.41436","title":"Efficacy and Safety of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis With and Without Fever at Baseline: Results From an Open‐Label, Active‐Treatment Extension Study","year":2020,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Novartis Pharma","keywords":"Medicine; Canakinumab; Arthritis; Internal medicine; Rheumatology; Bristol-Myers; Juvenile; Disease; Anakinra","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002702307,0.0006039097,0.001354123,0.0002445359,0.0002757138,0.0005005591,0.0002454254,0.0006301855,0.001065688],"category_scores_gemma":[0.002100565,0.0002482583,0.0007829439,0.0002680549,0.0004635314,0.0005706963,0.0002218593,0.0009895123,0.0003105463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003563708,"about_ca_system_score_gemma":0.0004162387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003397674,"about_ca_topic_score_gemma":0.0005155121,"domain_scores_codex":[0.9989985,0.0005158602,0.00008452957,0.0001366138,0.0001649014,0.00009958915],"domain_scores_gemma":[0.9977457,0.0007303011,0.0005902053,0.0002132862,0.0001843301,0.0005361713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5745629,0.029674,0.2511998,0.0008031997,0.002668247,0.0004451726,0.0006930197,0.0008766072,0.02587299,0.0000701159,0.0009541716,0.1121797],"study_design_scores_gemma":[0.133024,0.3245784,0.5338989,0.00006690124,0.001419727,0.0008772715,0.0001379411,0.001130391,0.003093221,0.00006248401,0.001654699,0.00005599866],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985501,0.0008834694,0.0000876914,0.00002759982,0.00001531346,0.00008695016,0.00009603693,0.000007034898,0.0002457772],"genre_scores_gemma":[0.9989337,0.0002449184,0.0001463395,0.00007703569,0.00006086184,0.0000773397,0.0002921151,0.000002453523,0.0001651439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002702307,"threshold_uncertainty_score":0.01429135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01920720217494851,"score_gpt":0.2787408321868954,"score_spread":0.2595336300119468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}