{"id":"W3041199890","doi":"10.1158/1557-3265.ovcasymp18-nt-117","title":"Abstract NT-117: INHIBITION OF PARG, SENSITIZES OVARIAN CANCER CELLS TO PARP INHIBITORS AND DNA DAMAGING AGENTS","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Poly ADP ribose polymerase; Synthetic lethality; DNA repair; Cancer research; Biology; Molecular biology; PARP inhibitor; Cisplatin; DNA damage; Blot; Ovarian cancer; Cell culture; Cancer; Chemistry; DNA; Polymerase; Biochemistry; Genetics; Gene; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007220055,0.000318258,0.0004086087,0.0002394934,0.0001280702,0.0002445518,0.000285778,0.0002768937,0.002829458],"category_scores_gemma":[0.00009338758,0.0001046603,0.0002398631,0.0002771996,0.0001699283,0.0001636041,0.0001472577,0.0006673771,0.0006884253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215138,"about_ca_system_score_gemma":0.0002447387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008077968,"about_ca_topic_score_gemma":0.0009671965,"domain_scores_codex":[0.9998927,0.00001408305,0.00001583628,0.00002066497,0.0000317384,0.00002501079],"domain_scores_gemma":[0.9999443,0.000008759691,0.000009556172,0.000009692877,0.000008969781,0.00001870023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000928497,0.000299374,0.0003865888,0.0002573267,0.00003159434,0.0001794151,0.00002601136,0.0002213652,0.9895392,0.0001050051,0.001193651,0.006831952],"study_design_scores_gemma":[0.000171045,0.001890639,0.005111671,0.00001332479,0.00005064627,0.0007010186,0.00003436123,0.0007762854,0.9816707,0.00003571132,0.009537261,0.00000721596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983822,0.005821816,0.001886265,0.000384884,0.0001971224,0.0001509765,0.003023478,0.000351785,0.004361607],"genre_scores_gemma":[0.9842355,0.002703281,0.00243047,0.000194777,0.00002700833,0.0001679675,0.005943039,0.00003958538,0.004258325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002829458,"threshold_uncertainty_score":0.009465516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.184126658303041,"score_gpt":0.5119869042786367,"score_spread":0.3278602459755957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}