{"id":"W3041281316","doi":"10.1016/j.jcf.2020.07.004","title":"Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus","year":2020,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Killam Trusts; Cystic Fibrosis Foundation","keywords":"Rhinovirus; Cystic fibrosis; Immunology; Ivacaftor; Respiratory epithelium; Medicine; Biology; Gene; Inflammation; Epithelium; Virology; Cystic fibrosis transmembrane conductance regulator; Genetics; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009510493,0.000517646,0.001139633,0.0003014166,0.0002640503,0.0001493716,0.0006791179,0.0001566964,0.001268896],"category_scores_gemma":[0.00608751,0.0002446846,0.0005648282,0.0006296017,0.0002430133,0.0002663892,0.00020136,0.0005870365,0.0003506559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000688169,"about_ca_system_score_gemma":0.000998572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004686967,"about_ca_topic_score_gemma":0.000004203212,"domain_scores_codex":[0.9953063,0.0003749258,0.001307904,0.0005064331,0.001715773,0.0007887334],"domain_scores_gemma":[0.9943343,0.002487645,0.0005425959,0.0006641118,0.0005898364,0.001381491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1085131,0.0002481212,0.0005259449,0.0001305389,0.0003791977,0.0006764951,0.0006131195,0.0001253409,0.8704411,0.000008810245,0.009375338,0.008962959],"study_design_scores_gemma":[0.009687262,0.02983842,0.03226265,0.0006874715,0.0009213217,0.001122866,0.0007021052,0.0005642046,0.6723676,0.00006720834,0.2511738,0.0006050323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757907,0.0007250872,0.001751779,0.0198324,0.0003046277,0.001038965,0.0004494149,0.00005579043,0.00005127534],"genre_scores_gemma":[0.9563554,0.000176849,0.03400815,0.003601388,0.002915255,0.00005988071,0.000007061478,0.0001054049,0.002770609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2417985,"threshold_uncertainty_score":0.9996441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04068712987660202,"score_gpt":0.3319623702321077,"score_spread":0.2912752403555057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}