{"id":"W3041304817","doi":"10.1172/jci.insight.137289","title":"RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NYU Grossman School of Medicine; Abbott Vascular; U.S. Public Health Service; National Cancer Institute; Terumo; York University; National Institutes of Health; Boston Scientific Corporation; ReCor Medical; National Heart, Lung, and Blood Institute; OrbusNeich Medical; Cook Medical; Fondation Leducq; Amgen","keywords":"Inflammation; Macrophage; IRF7; Cholesterol; Rage (emotion); Internal medicine; Diabetes mellitus; Medicine; Endocrinology; Chemistry; Immunology; Biology; Biochemistry; Innate immune system; Neuroscience; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000348519,0.0004201392,0.0002395978,0.0006139012,0.0001795792,0.0003316534,0.0002408288,0.000362597,0.002234237],"category_scores_gemma":[0.0001158761,0.000250556,0.0003076331,0.0001680899,0.0003289773,0.0001974733,0.0002358015,0.0008300332,0.0005675082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002655861,"about_ca_system_score_gemma":0.0002794834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005222387,"about_ca_topic_score_gemma":0.0008596531,"domain_scores_codex":[0.999738,0.0000537542,0.00002379092,0.00004143645,0.0000676408,0.0000752691],"domain_scores_gemma":[0.9997662,0.00002820217,0.00007653236,0.00003529412,0.00001621208,0.00007761661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002344408,0.0000754487,0.0001484262,0.00001352559,0.000003813687,0.00004431071,0.00001164596,0.00005501902,0.9982823,0.0001636161,0.00002313115,0.0009444436],"study_design_scores_gemma":[0.00003267273,0.0004331682,0.003639763,0.00000986037,0.00001432611,0.0002618998,0.00004049562,0.001063963,0.9929585,0.0001471803,0.001393839,0.000004419868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929144,0.0009533436,0.003207885,0.0001768853,0.00003502437,0.000022206,0.0003947757,0.0001682191,0.00212718],"genre_scores_gemma":[0.9898795,0.0008460441,0.003268306,0.0001151827,0.00001315713,0.00003115887,0.000492718,0.00005241405,0.005301687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234237,"threshold_uncertainty_score":0.007474303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01605764642074574,"score_gpt":0.268864679640507,"score_spread":0.2528070332197613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}