{"id":"W3041318796","doi":"10.1038/s41467-020-17409-9","title":"Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":475,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Horizon 2020 Framework Programme; European Commission; Engineering and Physical Sciences Research Council; National Institute for Health and Care Research; Imperial College Healthcare NHS Trust; Imperial College London; Research Councils UK; University of Bristol; Department of Health and Social Care","keywords":"Immunogenicity; Virology; Neutralizing antibody; Titer; Antibody; Biology; Neutralization; Virus; Antibody titer; RNA; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Immunology; Medicine; Gene; Genetics; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001734016,0.0005386745,0.0002739504,0.0002444136,0.00009870962,0.0002122967,0.0001562815,0.0004860575,0.001013127],"category_scores_gemma":[0.00009087629,0.0001492586,0.0002451024,0.00008536164,0.0001889475,0.0002281401,0.0001328049,0.0006950377,0.0003877351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001848203,"about_ca_system_score_gemma":0.0001656651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002045878,"about_ca_topic_score_gemma":0.0003211471,"domain_scores_codex":[0.9998878,0.00001499283,0.000007600736,0.00002789327,0.00003098217,0.00003066504],"domain_scores_gemma":[0.9999349,0.00001077216,0.00002051074,0.00000748729,0.00001050445,0.00001583657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000870947,0.00007102893,0.00004418095,0.00002131532,0.000003612393,0.00002062621,0.000006457818,0.00008068437,0.9987041,0.0000487693,0.00004645999,0.000865647],"study_design_scores_gemma":[0.00003669747,0.001430137,0.0005927361,0.000005076574,0.00001239677,0.000109581,0.00000894428,0.0007084654,0.9957672,0.00003726488,0.001288253,0.000003358823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884706,0.000735748,0.006755372,0.0002517776,0.0001016965,0.0000966619,0.0004365497,0.0002361889,0.002915479],"genre_scores_gemma":[0.985137,0.0007982116,0.006711784,0.0001968749,0.00003167359,0.0001204441,0.0008764077,0.00004652946,0.006081083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013127,"threshold_uncertainty_score":0.003389239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06094356826636183,"score_gpt":0.3885024733668661,"score_spread":0.3275589051005042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}