{"id":"W3041318796","doi":"10.1038/s41467-020-17409-9","title":"Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":475,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Horizon 2020 Framework Programme; European Commission; Engineering and Physical Sciences Research Council; National Institute for Health and Care Research; Imperial College Healthcare NHS Trust; Imperial College London; Research Councils UK; University of Bristol; Department of Health and Social Care","keywords":"Immunogenicity; Virology; Neutralizing antibody; Titer; Antibody; Biology; Neutralization; Virus; Antibody titer; RNA; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Immunology; Medicine; Gene; Genetics; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003263911,0.0002065998,0.0003550796,0.0002283329,0.0002395545,0.00008170841,0.0009972967,0.0002800578,0.000003842908],"category_scores_gemma":[0.0003210965,0.0001961705,0.00008701388,0.001338092,0.00006124643,0.0002380755,0.0004767039,0.001789253,0.00008236399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001545015,"about_ca_system_score_gemma":0.0002390168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006523816,"about_ca_topic_score_gemma":0.0007666672,"domain_scores_codex":[0.9983036,0.000191767,0.0004063892,0.0003561615,0.0003124505,0.0004296683],"domain_scores_gemma":[0.9981821,0.0002811679,0.0001057745,0.001182761,0.000176822,0.00007137614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001030237,0.0002249632,0.02737196,0.00009189501,0.00006547492,0.00002028304,0.001656102,6.8e-7,0.9681727,0.0008415118,0.000964672,0.0004867516],"study_design_scores_gemma":[0.002350455,0.0001472578,0.02182024,0.0001754007,0.00009139528,0.00002408793,0.0003648486,0.002115877,0.8041812,0.00005629719,0.1683708,0.000302114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655418,0.003473994,0.00001553012,0.02877918,0.0001015726,0.0004905328,0.00001199433,0.0002056791,0.001379748],"genre_scores_gemma":[0.9353002,0.0001962896,0.002485222,0.06175887,0.0001317028,0.0000430076,0.00004373671,0.00003853277,0.00000246868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1674062,"threshold_uncertainty_score":0.79996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06094356826636183,"score_gpt":0.3885024733668661,"score_spread":0.3275589051005042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}