{"id":"W3041397815","doi":"10.1101/2020.07.07.192294","title":"Metabolic fate of human immunoactive sterols in <i>Mycobacterium tuberculosis</i>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hyperion Technologies (Canada)","funders":"Universität des Saarlandes; National Institutes of Health; Office of International Science and Engineering; Russian Foundation for Basic Research; European Synchrotron Radiation Facility; National Institute of Allergy and Infectious Diseases; Belarusian Republican Foundation for Fundamental Research","keywords":"Oxysterol; Mycobacterium tuberculosis; Immune system; Innate immune system; Biology; Immunity; Enzyme; Drug discovery; Catabolism; Acquired immune system; Tuberculosis; Biochemistry; Microbiology; Immunology; Cholesterol; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104845,0.0001980384,0.0001302473,0.00009606851,0.0000903094,0.0001678575,0.0001283585,0.0001814067,0.001251993],"category_scores_gemma":[0.00007823888,0.00006121674,0.00016649,0.0001091139,0.0000958734,0.00007443269,0.00007310459,0.0001884757,0.0004609002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961701,"about_ca_system_score_gemma":0.0001205922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008379104,"about_ca_topic_score_gemma":0.0004579576,"domain_scores_codex":[0.9999555,0.00001137669,0.000002141113,0.00001061073,0.000009737811,0.00001056722],"domain_scores_gemma":[0.9999785,0.000003777584,0.000006556689,0.000002843264,0.000003980065,0.000004396034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005650229,0.00004007113,0.001100793,0.00008949254,0.00001365441,0.0001640053,0.00002304794,0.0007258619,0.9928887,0.0003226465,0.0002330865,0.003833652],"study_design_scores_gemma":[0.0000282132,0.0003324564,0.002402115,0.000008626643,0.00001620445,0.0002698228,0.00001988036,0.001472698,0.9903319,0.0001218705,0.004990774,0.000005355026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887313,0.004288938,0.003000239,0.0001989456,0.00003537608,0.00002463734,0.001057541,0.00006430827,0.002598686],"genre_scores_gemma":[0.9910953,0.001418428,0.002666965,0.00006685567,0.000009072783,0.00001175903,0.001571394,0.00001655174,0.003143638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251993,"threshold_uncertainty_score":0.004188359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861600364403025,"score_gpt":0.2473238573074805,"score_spread":0.2287078536634502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}