{"id":"W3041429193","doi":"10.1002/hbm.25133","title":"Nonlinear biomarker interactions in conversion from mild cognitive impairment to Alzheimer's disease","year":2020,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Genentech; National Institutes of Health; UK Dementia Research Institute; H. Lundbeck A/S; Servier; Eisai; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Department of Defence, Australian Government; Imperial College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; IXICO; Takeda Pharmaceutical Company; Pfizer; Biogen; BioClinica; Roche; University of Southern California; Medical Research Council; Johnson and Johnson; Meso Scale Diagnostics; Medical Research Council Canada; F. Hoffmann-La Roche; Novartis Pharmaceuticals Corporation; UK Research and Innovation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Biomarker; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Psychology; Alzheimer's disease; Hippocampal formation; Oncology; Neuroscience; Dementia; Cognitive impairment; Internal medicine; Disease; Cognition; Medicine; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001864541,0.0001775924,0.0002357313,0.0002655331,0.0001473918,0.0000475216,0.0000957461,0.0000284556,0.00254228],"category_scores_gemma":[0.0001815414,0.0001781771,0.000113767,0.0003890191,0.00005952544,0.0001263186,0.0001791955,0.0002506436,0.0005726909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007797358,"about_ca_system_score_gemma":0.0000831757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001190852,"about_ca_topic_score_gemma":0.0000204316,"domain_scores_codex":[0.9984066,0.0001217341,0.0002904453,0.0004680099,0.0003591951,0.0003539988],"domain_scores_gemma":[0.9988862,0.0001802059,0.0000485221,0.0001366745,0.0001164201,0.0006320101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002913563,0.001451288,0.8855353,0.0001788832,0.0007144244,0.001071278,0.006088044,0.000002460683,0.0743787,0.00003239017,0.02373552,0.003898156],"study_design_scores_gemma":[0.003526559,0.0002980425,0.982654,0.0006675114,0.0001157956,0.000001538494,0.002997719,0.001564906,0.000923413,0.00004266321,0.007006761,0.0002010825],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772043,0.0001057266,0.000719936,0.01890151,0.00006490853,0.001226076,0.00007661177,0.0000722832,0.001628709],"genre_scores_gemma":[0.985782,0.000004735686,0.0002749092,0.01295939,0.0002033295,0.00008774742,0.0004067621,0.00002461991,0.0002564992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09711871,"threshold_uncertainty_score":0.9983695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08812154740459745,"score_gpt":0.3651021228579603,"score_spread":0.2769805754533629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}