{"id":"W3041429193","doi":"10.1002/hbm.25133","title":"Nonlinear biomarker interactions in conversion from mild cognitive impairment to Alzheimer's disease","year":2020,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Genentech; National Institutes of Health; UK Dementia Research Institute; H. Lundbeck A/S; Servier; Eisai; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Department of Defence, Australian Government; Imperial College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; IXICO; Takeda Pharmaceutical Company; Pfizer; Biogen; BioClinica; Roche; University of Southern California; Medical Research Council; Johnson and Johnson; Meso Scale Diagnostics; Medical Research Council Canada; F. Hoffmann-La Roche; Novartis Pharmaceuticals Corporation; UK Research and Innovation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Biomarker; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Psychology; Alzheimer's disease; Hippocampal formation; Oncology; Neuroscience; Dementia; Cognitive impairment; Internal medicine; Disease; Cognition; Medicine; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008051756,0.00122139,0.000881365,0.001433499,0.0004463439,0.002161648,0.0007009783,0.0009502282,0.001169437],"category_scores_gemma":[0.01866516,0.000436805,0.001853635,0.0007677191,0.0008285345,0.0008731792,0.001557017,0.001559421,0.0003036026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007985808,"about_ca_system_score_gemma":0.0009230631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01197017,"about_ca_topic_score_gemma":0.01027077,"domain_scores_codex":[0.997602,0.001359751,0.0001567644,0.0004408919,0.0002701095,0.0001704617],"domain_scores_gemma":[0.9882181,0.008876531,0.001396577,0.0005844,0.0005867219,0.0003377663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001625356,0.0004010531,0.910402,0.0001135267,0.001589417,0.0003935275,0.0003054113,0.06118436,0.002242483,0.0005092993,0.0004421832,0.0207915],"study_design_scores_gemma":[0.00005017955,0.0006740247,0.5419835,0.0000791263,0.0005613943,0.0005044304,0.0002424044,0.4462724,0.002110662,0.006851299,0.0005877642,0.00008280969],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881063,0.0005371679,0.009963889,0.0002594509,0.00002459764,0.00004513386,0.0003087709,0.0001239125,0.0006308281],"genre_scores_gemma":[0.9983203,0.00005553436,0.00126197,0.00002719483,0.00000651341,0.0000104224,0.0001537713,0.00000635542,0.0001579315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01197017,"threshold_uncertainty_score":0.04258227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08812154740459745,"score_gpt":0.3651021228579603,"score_spread":0.2769805754533629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}