{"id":"W3041489599","doi":"10.1172/jci137536","title":"Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Medical Research Council; Medical Research Council; Duke-NUS Medical School; Wellcome Trust; Wellcome","keywords":"Dengue virus; Dengue fever; PCSK9; Viremia; Virology; Biology; Antibody-dependent enhancement; Cholesterol; Immunology; LDL receptor; Flavivirus; Virus; Lipoprotein; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154779,0.0001319166,0.0001824652,0.0001054392,0.0001096566,0.0002446299,0.00006241375,0.0001331375,0.001559338],"category_scores_gemma":[0.0001343075,0.00006711611,0.0001967546,0.0001264566,0.0001441374,0.000118112,0.0001589281,0.0006280218,0.0001600152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499715,"about_ca_system_score_gemma":0.0001811234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005373163,"about_ca_topic_score_gemma":0.0008598296,"domain_scores_codex":[0.9998747,0.0000226317,0.0000144238,0.00002064547,0.00002232739,0.00004527193],"domain_scores_gemma":[0.9999368,0.00001033704,0.00001681177,0.000008483911,0.00000674536,0.00002069868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00211035,0.0002172482,0.008859542,0.00007452787,0.00005219603,0.0001290183,0.00004100068,0.0001964691,0.9763275,0.0002127969,0.0002559716,0.01152335],"study_design_scores_gemma":[0.0001877155,0.003487903,0.2168221,0.00002228026,0.0001356956,0.0009824936,0.0001856275,0.002043799,0.7696393,0.0004253727,0.006049053,0.00001859022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976892,0.0005652978,0.0005073943,0.0001027062,0.00003913846,0.00001998288,0.0003214467,0.00001981508,0.0007349692],"genre_scores_gemma":[0.9977704,0.0004219677,0.0003593434,0.00004915609,0.00000722639,0.0000170198,0.000384964,0.00000445487,0.0009854572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559338,"threshold_uncertainty_score":0.005216539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1139587179966621,"score_gpt":0.4184368176407498,"score_spread":0.3044780996440877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}