{"id":"W3041489599","doi":"10.1172/jci137536","title":"Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Medical Research Council; Medical Research Council; Duke-NUS Medical School; Wellcome Trust; Wellcome","keywords":"Dengue virus; Dengue fever; PCSK9; Viremia; Virology; Biology; Antibody-dependent enhancement; Cholesterol; Immunology; LDL receptor; Flavivirus; Virus; Lipoprotein; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0006070553,0.0001188576,0.0004896772,0.00006903632,0.00004523454,0.00004314687,0.00008615805,0.00007697226,0.00003360422],"category_scores_gemma":[0.01161461,0.00008095276,0.000217312,0.0001016921,0.00009141066,0.0002262663,0.00004702452,0.000300259,0.00001393351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009659728,"about_ca_system_score_gemma":0.0002966729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003232105,"about_ca_topic_score_gemma":7.005228e-7,"domain_scores_codex":[0.9980923,0.0002586241,0.0009655536,0.0001894916,0.0003718447,0.0001221673],"domain_scores_gemma":[0.9972138,0.0004901868,0.0004304681,0.0001291425,0.0001784312,0.001557909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005859008,0.0002018076,0.8953812,0.00008850243,0.0001049434,0.0003181266,0.0003372359,0.000007662309,0.07087017,0.0001283307,0.008513406,0.01818958],"study_design_scores_gemma":[0.002531196,0.0008619144,0.9860383,0.0002852947,0.0002975449,0.00000733581,0.00008299814,0.0003324412,0.006092558,0.0007714628,0.00258805,0.0001108499],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9525132,0.0003344492,0.0002260263,0.04648386,0.0002130999,0.00018257,0.00001105721,0.00001309023,0.00002269284],"genre_scores_gemma":[0.9722263,0.00005777381,0.001024578,0.02566535,0.0009400772,0.000003279583,0.000003535983,0.00001246152,0.00006660793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09065713,"threshold_uncertainty_score":0.996711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1139587179966621,"score_gpt":0.4184368176407498,"score_spread":0.3044780996440877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}