{"id":"W3041504593","doi":"10.1101/2020.07.06.20147520","title":"A Trans-Omic Mendelian Randomization Study of Parental Lifespan Uncovers Novel Aging Biology and Drug Candidates for Human Healthspan Extension","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Common Fund; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; NIH Office of the Director; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health","keywords":"Phenome; Mendelian randomization; Biology; Genetics; Epistasis; Gene; Mendelian inheritance; Haptoglobin; Computational biology; Transcriptome; Genetic architecture; Disease; Longevity; Genotype; Evolutionary biology; Gene expression; Quantitative trait locus; Genome; Medicine; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003905136,0.0003484775,0.0007215436,0.0008319364,0.000269693,0.0005578144,0.0002264169,0.0004128088,0.002668271],"category_scores_gemma":[0.006833469,0.0001519425,0.0006942449,0.0009522054,0.0004751305,0.0002786171,0.0004703597,0.0005384276,0.0002049776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140455,"about_ca_system_score_gemma":0.0004118275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009537517,"about_ca_topic_score_gemma":0.0009149584,"domain_scores_codex":[0.9979923,0.0009698555,0.0001004485,0.0006290774,0.0002330481,0.00007534411],"domain_scores_gemma":[0.9964359,0.001842068,0.0006619099,0.0008733636,0.00008733565,0.00009950995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005763239,0.0002150073,0.5330989,0.0006402053,0.005204991,0.003910458,0.0005895435,0.01051351,0.2115659,0.02700533,0.006204074,0.1952887],"study_design_scores_gemma":[0.0005222835,0.001798279,0.7990756,0.0001248441,0.003704271,0.00973172,0.0003749398,0.05485415,0.05194121,0.05156017,0.0261519,0.0001606392],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8745065,0.00202335,0.1137956,0.001016995,0.0001056632,0.00005755689,0.005093586,0.000777713,0.002622954],"genre_scores_gemma":[0.9795911,0.0005135412,0.01725092,0.0002242871,0.00004812938,0.00004142678,0.001378386,0.00008783409,0.0008644357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003905136,"threshold_uncertainty_score":0.02065253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02878517760653464,"score_gpt":0.3232875093934485,"score_spread":0.2945023317869139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}