{"id":"W3041523647","doi":"10.1053/j.gastro.2020.07.003","title":"High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":199,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Research Council; Ministry of Science and Technology, Israel; Israel Science Foundation; Sun Yat-sen University; Wellcome Trust; Deutsches Krebsforschungszentrum; Garvan Institute of Medical Research; Canadian Institute for Advanced Research; Leona M. and Harry B. Helmsley Charitable Trust; Bill and Melinda Gates Foundation; Howard Hughes Medical Institute","keywords":"Tight junction; Barrier function; Cell biology; Biology; Intestinal epithelium; Lipopolysaccharide; Intestinal mucosa; Immune system; Tumor necrosis factor alpha; Inflammation; Gut flora; Chemistry; Epithelium; Immunology; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002650582,0.0005993742,0.0007653284,0.0005025927,0.0005076262,0.0007148682,0.0003664639,0.0003635279,0.002812876],"category_scores_gemma":[0.0002226642,0.0002041683,0.000591716,0.000571136,0.0001570169,0.0001865592,0.0003075146,0.0005193321,0.0008376641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004506705,"about_ca_system_score_gemma":0.0006389277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001644062,"about_ca_topic_score_gemma":0.005557531,"domain_scores_codex":[0.9997767,0.00002156489,0.00001238077,0.00003919955,0.00009768095,0.00005250695],"domain_scores_gemma":[0.9998765,0.00004041176,0.00002061324,0.00001190057,0.00002686628,0.00002368972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002552194,0.0001556006,0.001364489,0.0001233838,0.00005183664,0.00009631454,0.00001258708,0.0002074876,0.9931544,0.00006078132,0.000539343,0.003978495],"study_design_scores_gemma":[0.00009118776,0.001192721,0.03108298,0.00001827927,0.0003589951,0.0005114148,0.00009032683,0.002548143,0.955988,0.0001031504,0.00798989,0.00002499026],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976396,0.005677444,0.005453039,0.0003421466,0.00007185608,0.0001733644,0.007440535,0.0004868027,0.003958879],"genre_scores_gemma":[0.9626467,0.005210526,0.008699408,0.0002921426,0.00003429771,0.0002216444,0.01301361,0.00008718502,0.009794421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002812876,"threshold_uncertainty_score":0.009409964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01768268055455093,"score_gpt":0.2198429880619993,"score_spread":0.2021603075074484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}