{"id":"W3041532210","doi":"10.1158/0008-5472.can-20-0447","title":"Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Center for Chronic Disease Prevention and Health Promotion; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Cancer Institute; Cancer Council Victoria; National Institute of Environmental Health Sciences; Ministerio de Ciencia y Tecnología; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Ministero della Salute; Grantová Agentura České Republiky; European Cooperation in Science and Technology; Ministerstvo Zdravotnictví Ceské Republiky; California Department of Public Health; Pancreatic Cancer Action Network; U.S. Department of Defense; World Health Organization; National Institutes of Health; U.S. Department of Health and Human Services; Lustgarten Foundation; National Human Genome Research Institute; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública","keywords":"Inflammatory bowel disease; Pancreatitis; Ulcerative colitis; Genome-wide association study; Medicine; Disease; Genetic predisposition; Genetic association; Primary sclerosing cholangitis; Internal medicine; Gastroenterology; Biology; Genotype; Single-nucleotide polymorphism; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008536047,0.0001653689,0.0003684052,0.00009771578,0.0002369017,0.000037646,0.0002698306,0.00006831249,0.000181436],"category_scores_gemma":[0.003516487,0.0001477159,0.00003195705,0.0003301803,0.0001476637,0.00009234883,0.0005570463,0.0005325417,0.0001083307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001171477,"about_ca_system_score_gemma":0.0008091882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005513373,"about_ca_topic_score_gemma":0.000568417,"domain_scores_codex":[0.9971332,0.0006513989,0.0002733041,0.0007981167,0.0006133419,0.0005306721],"domain_scores_gemma":[0.9979255,0.0005402638,0.00007417998,0.0007108348,0.0002280918,0.0005210813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004530072,0.0001951126,0.9948076,0.0001518338,0.0002457712,0.0005975851,0.0009545026,0.000006984094,0.001032072,0.000001581379,0.0008090174,0.0007449129],"study_design_scores_gemma":[0.00172093,0.002157074,0.9947354,0.00006212909,0.0004256494,0.00001322052,0.0004033579,0.00004689565,0.00006020412,0.00003851372,0.0002203552,0.0001162877],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988389,0.007160184,0.00002357182,0.002244753,0.00004035287,0.001773498,0.0002632187,0.00005084634,0.00005459546],"genre_scores_gemma":[0.9978414,0.0007234764,0.0001200828,0.000166493,0.0005219558,0.0003051108,0.00008360545,0.00002460645,0.0002132291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009452459,"threshold_uncertainty_score":0.6023679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0744868467072635,"score_gpt":0.3765034414986013,"score_spread":0.3020165947913378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}