{"id":"W3041532210","doi":"10.1158/0008-5472.can-20-0447","title":"Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Center for Chronic Disease Prevention and Health Promotion; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Cancer Institute; Cancer Council Victoria; National Institute of Environmental Health Sciences; Ministerio de Ciencia y Tecnología; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Ministero della Salute; Grantová Agentura České Republiky; European Cooperation in Science and Technology; Ministerstvo Zdravotnictví Ceské Republiky; California Department of Public Health; Pancreatic Cancer Action Network; U.S. Department of Defense; World Health Organization; National Institutes of Health; U.S. Department of Health and Human Services; Lustgarten Foundation; National Human Genome Research Institute; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública","keywords":"Inflammatory bowel disease; Pancreatitis; Ulcerative colitis; Genome-wide association study; Medicine; Disease; Genetic predisposition; Genetic association; Primary sclerosing cholangitis; Internal medicine; Gastroenterology; Biology; Genotype; Single-nucleotide polymorphism; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001714562,0.0003155614,0.0003963371,0.0009913434,0.0002815384,0.000741902,0.0004111712,0.0004734944,0.002969801],"category_scores_gemma":[0.006477563,0.0002530632,0.0009269799,0.001470443,0.0003717739,0.000231485,0.0004499852,0.0006998823,0.0001973199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407006,"about_ca_system_score_gemma":0.0002089052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003232964,"about_ca_topic_score_gemma":0.00287665,"domain_scores_codex":[0.9985136,0.0006526988,0.0001316038,0.0004018062,0.0001878146,0.0001123942],"domain_scores_gemma":[0.9929919,0.003743499,0.001623055,0.0008417191,0.0003264438,0.0004733821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003916955,0.00002570566,0.9926323,0.00002767724,0.0009359927,0.0001183485,0.00003743181,0.0002685902,0.001983687,0.00007957864,0.0002244949,0.003274498],"study_design_scores_gemma":[0.0000344429,0.00007875499,0.9969694,0.000008969916,0.0004804081,0.000277304,0.00005798302,0.001165827,0.0003703683,0.0001655981,0.0003860699,0.000004992496],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957576,0.0009895095,0.001647545,0.0001709292,0.00001673114,0.000006794955,0.0008200014,0.00003671245,0.0005542196],"genre_scores_gemma":[0.9986778,0.0001567007,0.0005406915,0.00003088506,0.00002288289,0.000005364183,0.0004184511,0.000006820044,0.0001403984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003232964,"threshold_uncertainty_score":0.009934962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0744868467072635,"score_gpt":0.3765034414986013,"score_spread":0.3020165947913378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}