{"id":"W3041534305","doi":"10.1038/s41598-020-67466-9","title":"The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF-12","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Campus France; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; European Commission; Région Occitanie Pyrénées-Méditerranée; Wellcome Trust; McGill University; National Institutes of Health; University of Georgia","keywords":"Dirofilaria immitis; Biology; Moulting; Caenorhabditis elegans; Nematode; Larva; Receptor; Clade; Nuclear receptor; Host (biology); Parasite hosting; Cell biology; Gene; Zoology; Helminths; Genetics; Phylogenetics; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000448758,0.0001886897,0.0001204994,0.0001195413,0.000112132,0.0001628423,0.00007237026,0.000173822,0.001456374],"category_scores_gemma":[0.00007849543,0.0001108659,0.0001393225,0.00005215927,0.0001384326,0.00006974462,0.0001441841,0.0001991235,0.0002358917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001551999,"about_ca_system_score_gemma":0.0001003135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008628383,"about_ca_topic_score_gemma":0.00167809,"domain_scores_codex":[0.9999522,0.000007423047,0.000002426636,0.0000102449,0.00001328644,0.00001451363],"domain_scores_gemma":[0.9999599,0.000004818583,0.0000179632,0.000003157023,0.00000449281,0.000009519737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006357369,0.000006900118,0.001264774,0.00004215808,0.000005237003,0.00008347158,0.00001088787,0.0001174343,0.9967973,0.00006369075,0.00006162902,0.001483054],"study_design_scores_gemma":[0.00003712317,0.0008328394,0.126321,0.00002925687,0.00004831396,0.001449898,0.0002121437,0.002319751,0.8527373,0.0002290138,0.01576392,0.0000195877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944063,0.001685036,0.001316607,0.00007046529,0.00001899958,0.00001131129,0.0002110738,0.00005563115,0.002224597],"genre_scores_gemma":[0.9966304,0.0005548619,0.0007032477,0.00002410045,0.000002637994,0.000005396911,0.0002147109,0.000005262498,0.001859467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456374,"threshold_uncertainty_score":0.004872084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02890021845631164,"score_gpt":0.3002810516542301,"score_spread":0.2713808331979185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}