{"id":"W3041534305","doi":"10.1038/s41598-020-67466-9","title":"The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF-12","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Campus France; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; European Commission; Région Occitanie Pyrénées-Méditerranée; Wellcome Trust; McGill University; National Institutes of Health; University of Georgia","keywords":"Dirofilaria immitis; Biology; Moulting; Caenorhabditis elegans; Nematode; Larva; Receptor; Clade; Nuclear receptor; Host (biology); Parasite hosting; Cell biology; Gene; Zoology; Helminths; Genetics; Phylogenetics; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00109651,0.0001447316,0.000230463,0.000030528,0.0007394105,0.00008116362,0.0002774234,0.00003796927,0.000071581],"category_scores_gemma":[0.0007165486,0.00005469637,0.0001694054,0.0007338314,0.0004799685,0.00004815523,0.0003632208,0.0001804063,0.00004947006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007903725,"about_ca_system_score_gemma":0.0007511447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002766871,"about_ca_topic_score_gemma":0.00007016293,"domain_scores_codex":[0.9973251,0.0001805333,0.0005094114,0.0004428114,0.00118886,0.0003532742],"domain_scores_gemma":[0.997749,0.0001252323,0.0002807199,0.001211029,0.0003924718,0.0002415324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001996701,0.001541036,0.1522842,0.0003315689,0.002304068,0.0004272845,0.07001179,0.0001086318,0.459122,0.0004545927,0.2753405,0.03607765],"study_design_scores_gemma":[0.0005641896,0.0002098676,0.428546,0.0002839078,0.0001471768,0.0001020342,0.002140183,0.00006634794,0.3943529,0.0001411011,0.1732887,0.0001575978],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698592,0.00003854642,0.000009023758,0.02534649,0.000963236,0.001291203,0.00002223141,0.00001564542,0.002454432],"genre_scores_gemma":[0.9966967,0.000004181507,0.0001519465,0.0005667685,0.00004164732,0.00003156086,0.000008156508,0.00001414523,0.002484918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2762618,"threshold_uncertainty_score":0.5687022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02890021845631164,"score_gpt":0.3002810516542301,"score_spread":0.2713808331979185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}