{"id":"W3041546786","doi":"10.3389/fcell.2020.00546","title":"Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"Fundação Instituto de Pesquisas Econômicas; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Brain Tumour Foundation of Canada","keywords":"Medulloblastoma; Histone deacetylase; Epigenetics; Medicine; Vorinostat; Cancer; Ependymoma; Pediatric cancer; Cancer research; Histone; Acetylation; Cancer epigenetics; Histone deacetylase inhibitor; Oncology; Bioinformatics; Internal medicine; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004170251,0.0006559636,0.0009637562,0.001471493,0.0001790787,0.000718475,0.0006564579,0.00077452,0.003703651],"category_scores_gemma":[0.0004877581,0.0002172671,0.0004773697,0.001313032,0.0002617367,0.0008229371,0.0004758883,0.001773999,0.002193434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004490917,"about_ca_system_score_gemma":0.0005627799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006112013,"about_ca_topic_score_gemma":0.001719022,"domain_scores_codex":[0.9998975,0.00001673442,0.00001422425,0.00002029598,0.00003698537,0.00001436118],"domain_scores_gemma":[0.9998223,0.0000803162,0.00002607647,0.000005323956,0.00004357481,0.00002232646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000119076,0.00007962897,0.000140615,0.009469458,0.00008723782,0.0001841592,0.0000385703,0.0003531697,0.002691496,0.002926279,0.02611095,0.9577995],"study_design_scores_gemma":[0.00004454091,0.0001978774,0.0006794837,0.001922014,0.0001385436,0.001116451,0.00003162794,0.0001123849,0.001034743,0.001462095,0.993244,0.00001627791],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001958082,0.9982936,0.0001189651,0.0002192772,0.0001284247,0.000005877511,0.00003564256,0.00001207978,0.0009904263],"genre_scores_gemma":[0.0008269007,0.9980845,0.0001788746,0.0001701416,0.00008939989,0.000008765039,0.00005323284,0.000002476304,0.0005856031],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003703651,"threshold_uncertainty_score":0.01238996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835921150335878,"score_gpt":0.2919660180514365,"score_spread":0.2736068065480777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}