{"id":"W3041546786","doi":"10.3389/fcell.2020.00546","title":"Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"Fundação Instituto de Pesquisas Econômicas; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Brain Tumour Foundation of Canada","keywords":"Medulloblastoma; Histone deacetylase; Epigenetics; Medicine; Vorinostat; Cancer; Ependymoma; Pediatric cancer; Cancer research; Histone; Acetylation; Cancer epigenetics; Histone deacetylase inhibitor; Oncology; Bioinformatics; Internal medicine; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003071093,0.0005362026,0.001179145,0.0004450003,0.00008718656,0.0000246548,0.0002466971,0.0009266611,0.00001141694],"category_scores_gemma":[0.00007120326,0.0004681063,0.0001345066,0.0003356728,0.0004631016,0.000006304594,0.0004458743,0.0005993347,0.000007212602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004061404,"about_ca_system_score_gemma":0.0007777295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006914329,"about_ca_topic_score_gemma":0.00007402965,"domain_scores_codex":[0.9972024,0.0004554683,0.0006165801,0.001040142,0.0001090927,0.0005763071],"domain_scores_gemma":[0.9994245,0.00006596148,0.0001674002,0.0001460118,0.00001387267,0.0001822749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002310923,0.0001426747,0.003255122,0.002639571,0.000116726,0.0001872301,0.0003214597,9.621764e-7,0.004658794,0.000006311232,0.01571179,0.9727283],"study_design_scores_gemma":[0.0009814294,0.0003833442,0.00007404496,0.0002374086,0.00004484665,0.0001042636,0.0003110442,0.000007019415,0.00146281,0.00003257764,0.9955938,0.0007673898],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05581987,0.9425928,0.00006085924,0.0000551623,0.0005265219,0.0006011403,0.00006936627,0.00001274791,0.0002615534],"genre_scores_gemma":[0.01156088,0.9860368,0.001176715,0.0001229421,0.0002840173,0.000156175,0.0003905538,0.00004659144,0.0002252842],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.979882,"threshold_uncertainty_score":0.9997771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835921150335878,"score_gpt":0.2919660180514365,"score_spread":0.2736068065480777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}