{"id":"W3041578668","doi":"10.1016/s2213-2600(20)30190-9","title":"Once-daily, single-inhaler mometasone–indacaterol–glycopyrronium versus mometasone–indacaterol or twice-daily fluticasone–salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study","year":2020,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Novartis Pharmaceuticals Canada; Novartis Pharmaceuticals Corporation; Novartis","keywords":"Indacaterol; Medicine; Fluticasone; Salmeterol; Mometasone furoate; Asthma; Inhaler; Anesthesia; Internal medicine; Corticosteroid; Bronchodilator","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002307885,0.001995937,0.005255857,0.0006238591,0.0006515234,0.001300492,0.001610074,0.002762548,0.008335889],"category_scores_gemma":[0.00197448,0.001197287,0.003888977,0.0006660517,0.00197044,0.001657636,0.0005606084,0.004236284,0.001500566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000909991,"about_ca_system_score_gemma":0.001484104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001825408,"about_ca_topic_score_gemma":0.003482999,"domain_scores_codex":[0.9991615,0.0004047113,0.00006859085,0.0001500992,0.00005818581,0.000156896],"domain_scores_gemma":[0.998582,0.0005235933,0.0002484696,0.0001427557,0.00007685508,0.000426355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.989877,0.00320833,0.0001222308,0.0003564046,0.000431518,0.00001615742,0.00003484491,0.00008518928,0.001706173,0.00003418862,0.0001974869,0.003930388],"study_design_scores_gemma":[0.9665122,0.03230477,0.000545215,0.00001154134,0.0002233885,0.000008993769,0.00001111466,0.00008276845,0.0001286382,0.00003369736,0.0001294545,0.000008280544],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868623,0.004638184,0.0007899999,0.0007314651,0.0008952555,0.003318058,0.001060232,0.0001501223,0.001554443],"genre_scores_gemma":[0.9839572,0.003166249,0.002441611,0.001172101,0.000847875,0.003954363,0.0009809573,0.00004852505,0.0034312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008335889,"threshold_uncertainty_score":0.02788633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1146655548063409,"score_gpt":0.3503536554145601,"score_spread":0.2356881006082192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}