{"id":"W3041578668","doi":"10.1016/s2213-2600(20)30190-9","title":"Once-daily, single-inhaler mometasone–indacaterol–glycopyrronium versus mometasone–indacaterol or twice-daily fluticasone–salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study","year":2020,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Novartis Pharmaceuticals Canada; Novartis Pharmaceuticals Corporation; Novartis","keywords":"Indacaterol; Medicine; Fluticasone; Salmeterol; Mometasone furoate; Asthma; Inhaler; Anesthesia; Internal medicine; Corticosteroid; Bronchodilator","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.003163446,0.001693735,0.006953487,0.0008331527,0.0004282774,0.0001791729,0.001259962,0.0004351722,0.001114735],"category_scores_gemma":[0.002119528,0.0008662397,0.0006063457,0.002090499,0.001104846,0.0005098963,0.0002756393,0.001822565,0.0002340679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004089395,"about_ca_system_score_gemma":0.0007453194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007196059,"about_ca_topic_score_gemma":0.00009429957,"domain_scores_codex":[0.9882278,0.002085165,0.002970105,0.0018445,0.002890581,0.001981877],"domain_scores_gemma":[0.9926174,0.001658115,0.001458327,0.001924871,0.0007855701,0.001555763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9593202,0.005401811,0.01902047,0.0002869361,0.00246697,0.001252556,0.002428141,0.00007404156,0.002597907,0.00001004263,0.003643166,0.00349768],"study_design_scores_gemma":[0.9111607,0.05641664,0.009048965,0.0004929433,0.003166003,0.00002015231,0.002033394,0.0004797417,0.0007675459,0.00000213682,0.01548913,0.0009226582],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678786,0.002658293,0.0001051324,0.009501578,0.0006935254,0.01798492,0.00008008253,0.0003839152,0.0007139263],"genre_scores_gemma":[0.9835994,0.00005537816,0.00005368749,0.01046452,0.002876944,0.002387849,0.0001155997,0.0002555856,0.0001909884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05101483,"threshold_uncertainty_score":0.9997984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1146655548063409,"score_gpt":0.3503536554145601,"score_spread":0.2356881006082192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}