{"id":"W3041579002","doi":"10.1136/esmoopen-2020-000673","title":"Phase I, open-label, multicentre study of buparlisib in combination with temozolomide or with concomitant radiation therapy and temozolomide in patients with newly diagnosed glioblastoma","year":2020,"lang":"en","type":"article","venue":"ESMO Open","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharma","keywords":"Temozolomide; Concomitant; Medicine; Glioblastoma; Radiation therapy; Oncology; Internal medicine; Open label; Clinical trial; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718894,0.0002693658,0.0007113144,0.0001431126,0.00005722628,0.0001068851,0.0002419315,0.00005594214,0.00003967541],"category_scores_gemma":[0.00007409008,0.0001577876,0.000009033483,0.0006153907,0.00005853584,0.0004765757,0.0001186311,0.0001413161,0.0000025566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001200033,"about_ca_system_score_gemma":0.0001515357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003832642,"about_ca_topic_score_gemma":0.01006663,"domain_scores_codex":[0.9983645,0.0001557214,0.0004244303,0.0004964505,0.0003293852,0.0002295294],"domain_scores_gemma":[0.998933,0.0002024729,0.0002895666,0.0002746533,0.000130529,0.0001698219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04750469,0.02823987,0.9060903,0.00002559231,0.0002238335,0.0005623538,0.004461326,0.00005610602,0.00003674225,0.00001308075,0.0001113655,0.01267474],"study_design_scores_gemma":[0.3051899,0.05053639,0.6404307,0.0002360699,0.00008377797,0.000003949058,0.001810757,0.0004425285,0.001043958,0.000001538606,0.0000615856,0.0001587293],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897578,0.00005089773,0.000002843895,0.001004838,0.00001379537,0.009050156,0.00001908977,0.00001442739,0.00008610429],"genre_scores_gemma":[0.9984086,0.00004845416,0.0005790008,0.0003957381,0.000007915025,0.0004467753,0.00006509049,0.00003844443,0.000009946051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2656595,"threshold_uncertainty_score":0.6434392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380584647365548,"score_gpt":0.3106767153573926,"score_spread":0.2768708688837371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}