{"id":"W3041579002","doi":"10.1136/esmoopen-2020-000673","title":"Phase I, open-label, multicentre study of buparlisib in combination with temozolomide or with concomitant radiation therapy and temozolomide in patients with newly diagnosed glioblastoma","year":2020,"lang":"en","type":"article","venue":"ESMO Open","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharma","keywords":"Temozolomide; Concomitant; Medicine; Glioblastoma; Radiation therapy; Oncology; Internal medicine; Open label; Clinical trial; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002145398,0.002593032,0.003558988,0.0006951297,0.0006236507,0.001291889,0.001666649,0.001441362,0.00277764],"category_scores_gemma":[0.00116668,0.001279664,0.00183592,0.0007898663,0.001307683,0.001460348,0.0006113555,0.00389121,0.0009563144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002004195,"about_ca_system_score_gemma":0.003167597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391983,"about_ca_topic_score_gemma":0.004973292,"domain_scores_codex":[0.9990236,0.0004448044,0.00005760741,0.0001952288,0.0001021772,0.0001765647],"domain_scores_gemma":[0.9988127,0.00009349122,0.0003143876,0.0001054817,0.0001142452,0.000559809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7997924,0.08356847,0.01067914,0.001050317,0.002497702,0.0002391736,0.0004235715,0.002013328,0.04561533,0.0001343353,0.003336251,0.05064998],"study_design_scores_gemma":[0.5033699,0.4743223,0.01678029,0.00002751392,0.000596836,0.0002174608,0.00006838937,0.0006987075,0.002402325,0.0000779262,0.001394809,0.00004358169],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914943,0.001900027,0.0005914209,0.0003195946,0.0001198882,0.003754546,0.0008569557,0.00009463971,0.000868616],"genre_scores_gemma":[0.9885141,0.001358226,0.001882381,0.0007665111,0.0001641148,0.003940485,0.001987331,0.00003529508,0.001351457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003558988,"threshold_uncertainty_score":0.01454151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380584647365548,"score_gpt":0.3106767153573926,"score_spread":0.2768708688837371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}