{"id":"W3041647981","doi":"10.1021/acschemneuro.0c00333","title":"Pannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlook","year":2020,"lang":"en","type":"review","venue":"ACS Chemical Neuroscience","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Research Institute; Alberta Children's Hospital Foundation","keywords":"Pannexin; Neuroscience; Biology; Mechanism (biology); Adenosine; Intracellular; Transmembrane protein; Pharmacology; Cell biology; Receptor; Gap junction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004690536,0.0008344285,0.0009931854,0.001751337,0.0002360287,0.0009041249,0.0007696695,0.001251712,0.004472703],"category_scores_gemma":[0.0004049161,0.0002820209,0.000404862,0.001291567,0.0003455389,0.001403301,0.0006341551,0.001968065,0.002847111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005378433,"about_ca_system_score_gemma":0.0006253854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005418086,"about_ca_topic_score_gemma":0.001459331,"domain_scores_codex":[0.9999019,0.00001458404,0.00001115919,0.00001886239,0.00003728856,0.00001618116],"domain_scores_gemma":[0.9998657,0.00005131937,0.00001682751,0.000004667019,0.00004013861,0.00002135659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001134971,0.0001506714,0.00009099209,0.01383047,0.0000638667,0.0002912894,0.0000588842,0.0007063962,0.0068495,0.008371572,0.05173355,0.9177393],"study_design_scores_gemma":[0.00002699961,0.0001612846,0.0003232413,0.002030295,0.00007574006,0.0008530644,0.00003354246,0.0001645365,0.001062792,0.002613669,0.992636,0.00001881249],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002159394,0.99695,0.0002219911,0.0004920027,0.0004138477,0.000007212822,0.00002624408,0.00001590478,0.00165682],"genre_scores_gemma":[0.000710673,0.9973884,0.000232969,0.0003549724,0.0002181232,0.00001052592,0.00003651261,0.000002734182,0.001044916],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004472703,"threshold_uncertainty_score":0.01496267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02695623292752156,"score_gpt":0.2962566569938884,"score_spread":0.2693004240663668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}