{"id":"W3041647981","doi":"10.1021/acschemneuro.0c00333","title":"Pannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlook","year":2020,"lang":"en","type":"review","venue":"ACS Chemical Neuroscience","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Research Institute; Alberta Children's Hospital Foundation","keywords":"Pannexin; Neuroscience; Biology; Mechanism (biology); Adenosine; Intracellular; Transmembrane protein; Pharmacology; Cell biology; Receptor; Gap junction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007719089,0.0004293582,0.0007049705,0.00004923474,0.00008866654,0.00006617696,0.0004055322,0.0004441787,0.00002089531],"category_scores_gemma":[0.0002829905,0.0003379542,0.0001772643,0.000238807,0.0004390626,0.000005365772,0.0004587693,0.0003581137,0.00001415762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001227098,"about_ca_system_score_gemma":0.0001845523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002716714,"about_ca_topic_score_gemma":4.045018e-7,"domain_scores_codex":[0.9979033,0.0001025157,0.0003524205,0.001100125,0.0001476973,0.0003939525],"domain_scores_gemma":[0.9991634,0.00003520187,0.000169458,0.0003834559,0.00004019298,0.0002082218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002401007,0.00004590104,0.000005029186,0.0009422894,0.00002886875,0.00004589741,0.0000266763,3.223679e-7,0.6741681,0.0003340826,0.0007121603,0.3236666],"study_design_scores_gemma":[0.0001272399,0.0001988413,0.000001196625,0.0001610144,0.00005802512,0.0002941798,0.00000296899,0.000005083478,0.02925988,0.0003031651,0.9692173,0.0003711224],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003729277,0.9949944,0.00006019266,0.000213696,0.0003244489,0.000411654,0.0001158103,0.00002774142,0.0001227904],"genre_scores_gemma":[0.02123493,0.9750769,0.00005642105,0.002752661,0.0004361759,0.00003763599,0.0001776341,0.00004707265,0.0001805914],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9685051,"threshold_uncertainty_score":0.9999073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02695623292752156,"score_gpt":0.2962566569938884,"score_spread":0.2693004240663668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}