{"id":"W3041665519","doi":"10.1080/2162402x.2020.1792058","title":"Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination","year":2020,"lang":"en","type":"article","venue":"OncoImmunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Cancerföreningen i Stockholm; Medicinska Forskningsrådet; Knut och Alice Wallenbergs Stiftelse; Kommunfullmäktige, Stockholms Stad; Stiftelsen för Strategisk Forskning","keywords":"Medicine; Immunotherapy; Melanoma; Cohort; T cell; Internal medicine; Adoptive cell transfer; Vaccination; Oncology; Immune system; Immunology; Surgery; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004022451,0.0003158317,0.0006257956,0.0002063896,0.0001925594,0.0002305933,0.0001415751,0.0002277543,0.0005660483],"category_scores_gemma":[0.0004133218,0.000122169,0.0002716356,0.00009904688,0.0001755535,0.000156249,0.0001257569,0.0005065312,0.0001448556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593955,"about_ca_system_score_gemma":0.0001432812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002978241,"about_ca_topic_score_gemma":0.0006163263,"domain_scores_codex":[0.9998516,0.00004381436,0.00001801691,0.0000279388,0.00001931185,0.00003928487],"domain_scores_gemma":[0.9998121,0.0000647284,0.00002785756,0.00002574453,0.00001226466,0.00005728512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.02687217,0.005972431,0.1361648,0.0004937722,0.000512076,0.01031557,0.0006345417,0.00436069,0.5900256,0.0002433991,0.002031809,0.2223732],"study_design_scores_gemma":[0.00629827,0.2221924,0.5118693,0.0000617355,0.0008776489,0.0314989,0.0002212388,0.01102397,0.203027,0.0002348062,0.01263966,0.00005511582],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980831,0.00057056,0.0003865454,0.00005034937,0.00001227925,0.00006049373,0.00005077084,0.00002360903,0.0007623285],"genre_scores_gemma":[0.9990784,0.000127453,0.0002687302,0.00004187886,0.0000198482,0.00003104258,0.0001183761,0.000005199073,0.0003091008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006257956,"threshold_uncertainty_score":0.00212729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0522399937909423,"score_gpt":0.3173448581663302,"score_spread":0.2651048643753879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}