{"id":"W3041681986","doi":"10.3389/fgene.2020.00615","title":"A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; Wayne State University; American Diabetes Association","keywords":"Gene knockdown; Biology; Transcriptome; Locus (genetics); Gene; Exon; Gene expression; Small interfering RNA; RNA; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002665552,0.0003046056,0.0003422526,0.00007876193,0.0001626068,0.00006851138,0.0004270731,0.0002935216,0.00004071742],"category_scores_gemma":[0.00008418791,0.000270143,0.0001139655,0.0003641177,0.0001945182,0.00000799276,0.0001978472,0.0003661209,0.00001075426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004417191,"about_ca_system_score_gemma":0.00009892092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001971449,"about_ca_topic_score_gemma":0.00007049247,"domain_scores_codex":[0.9979305,0.0002284382,0.0002745277,0.0006892468,0.0003034012,0.0005738997],"domain_scores_gemma":[0.9991779,0.00001353696,0.00008274547,0.0003703609,0.00007772313,0.0002777728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001674658,0.00003698423,0.002287538,0.00006619207,0.0002108764,0.00001606234,0.000767193,0.0005198298,0.9614,0.00000241725,0.005670056,0.02885533],"study_design_scores_gemma":[0.001349421,0.0007819788,0.003513869,0.00002294685,0.0001353452,0.000006447603,0.0001204658,0.008581677,0.9628127,0.00004540639,0.02222776,0.0004019377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9161532,0.04213713,0.04001033,0.0003841915,0.0004083151,0.0006866424,0.0001207585,0.00001716849,0.00008227365],"genre_scores_gemma":[0.9860843,0.009872407,0.002460334,0.0008633726,0.0003666418,0.00004687375,0.00007279288,0.00008906229,0.0001442526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06993107,"threshold_uncertainty_score":0.9999751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009254005215312828,"score_gpt":0.2338695254697209,"score_spread":0.2246155202544081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}