{"id":"W3041798847","doi":"10.1093/nar/gkaa592","title":"Human GTPBP5 (MTG2) fuels mitoribosome large subunit maturation by facilitating 16S rRNA methylation","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; American Heart Association; Centre National de la Recherche Scientifique; Université de Lorraine; Muscular Dystrophy Association; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Mitochondrial ribosome; Ribosome; Protein subunit; Ribosomal RNA; Methylation; Ribosomal protein; Methyltransferase; Mitochondrion; Biogenesis; Cell biology; Molecular biology; Biochemistry; RNA; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008279143,0.0004325987,0.0001871987,0.0001846132,0.0002203171,0.0002316005,0.0001926982,0.0003338541,0.001072761],"category_scores_gemma":[0.0001106801,0.00009518945,0.0002463756,0.0001561343,0.0001332621,0.0001282967,0.0002671143,0.0002606557,0.0003790402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004102717,"about_ca_system_score_gemma":0.0001670253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001364835,"about_ca_topic_score_gemma":0.002211269,"domain_scores_codex":[0.9999267,0.00001131777,0.00000636714,0.00002380453,0.00001910483,0.00001282354],"domain_scores_gemma":[0.999975,0.000003049702,0.000006367969,0.000004007275,0.000002517191,0.000009159729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001416182,0.000009423911,0.0005170974,0.00004319693,0.00000783834,0.00005451019,0.000009457638,0.00008326259,0.9969716,0.000218141,0.0001137125,0.00183005],"study_design_scores_gemma":[0.00001666576,0.00008742577,0.004917613,0.000008309721,0.00002132214,0.0002901038,0.00001700645,0.001615312,0.9849739,0.00009431007,0.007953491,0.000004433199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881718,0.003255005,0.005305048,0.0003008502,0.00005698823,0.0000158282,0.0009504785,0.0002909574,0.001653084],"genre_scores_gemma":[0.9932873,0.0007624953,0.00249458,0.00005189313,0.000007172492,0.0000131621,0.001293958,0.0000232538,0.002066266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001364835,"threshold_uncertainty_score":0.003588736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05889116378338399,"score_gpt":0.3661135079484971,"score_spread":0.3072223441651131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}