{"id":"W3041801873","doi":"10.1016/j.lfs.2020.118064","title":"IFNβ-induced exosomal linc-EPHA6-1 promotes cytotoxicity of NK cells by acting as a ceRNA for hsa-miR-4485-5p to up-regulate NKp46 expression","year":2020,"lang":"en","type":"article","venue":"Life Sciences","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Chinese Academy of Medical Sciences; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Cytotoxicity; Competing endogenous RNA; Cell biology; Biology; Cancer research; Downregulation and upregulation; Gene; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555708,0.0002222853,0.0002435979,0.0001045965,0.0002024099,0.0003311356,0.0001009177,0.0002578262,0.002413445],"category_scores_gemma":[0.0001477273,0.0001267562,0.0002707033,0.00008087604,0.0002300219,0.000271487,0.0002430887,0.0007391686,0.0006237393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736152,"about_ca_system_score_gemma":0.0002467442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003740646,"about_ca_topic_score_gemma":0.0006040207,"domain_scores_codex":[0.9997864,0.00002827996,0.0000248387,0.00005791133,0.0000508458,0.00005174654],"domain_scores_gemma":[0.9999441,0.00001003411,0.0000142961,0.000008326585,0.000007238134,0.00001592283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003465294,0.000021867,0.0002856223,0.0000522809,0.000008919599,0.00004394464,0.00001854096,0.00008697099,0.9971571,0.0001805764,0.00008412701,0.001713451],"study_design_scores_gemma":[0.00002673369,0.00009201154,0.002173016,0.000004097054,0.00001475831,0.0001333951,0.00002283082,0.0009217705,0.992976,0.00005748673,0.003574125,0.000003897483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883198,0.001873601,0.005584975,0.0002041693,0.0001855674,0.00003886152,0.0005692598,0.0001403156,0.00308356],"genre_scores_gemma":[0.991714,0.0004933668,0.00308549,0.0001145331,0.00002078307,0.0000448164,0.0005598806,0.00003346847,0.003933687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002413445,"threshold_uncertainty_score":0.008073807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02889331397620445,"score_gpt":0.296113396990991,"score_spread":0.2672200830147866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}