{"id":"W3041803319","doi":"10.1101/2020.07.07.20148098","title":"Reversal of Epigenetic Age with Diet and Lifestyle in a Pilot Randomized Clinical Trial","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University; Yale University","keywords":"Randomized controlled trial; Biological age; Clinical trial; Epigenetics; Intervention (counseling); Medicine; Gerontology; Biology; Internal medicine; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006830774,0.001350737,0.002251668,0.0003973754,0.0006313806,0.001062727,0.0006621381,0.001957508,0.006618603],"category_scores_gemma":[0.005654634,0.0004782471,0.001805447,0.0004681964,0.001367799,0.001037316,0.0006128162,0.001946446,0.0008502898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000615637,"about_ca_system_score_gemma":0.002129159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004880129,"about_ca_topic_score_gemma":0.0007827235,"domain_scores_codex":[0.9970801,0.001998452,0.0001752716,0.000329933,0.0001592147,0.0002568668],"domain_scores_gemma":[0.997048,0.001062854,0.0005499328,0.0003775472,0.0002829572,0.000678709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9710155,0.01099441,0.0005869759,0.0005314942,0.001016496,0.000051732,0.00005150437,0.0002169865,0.001879011,0.0003085186,0.001183523,0.01216379],"study_design_scores_gemma":[0.8981968,0.09790476,0.001268065,0.00005580355,0.0004663039,0.00002026523,0.00002027917,0.0003532666,0.0004418802,0.0003843325,0.0008747106,0.00001349609],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486299,0.003829993,0.005042475,0.002754219,0.002298653,0.03167377,0.001684841,0.0004297814,0.003656317],"genre_scores_gemma":[0.9199001,0.001676638,0.0126802,0.002372384,0.001161166,0.05547323,0.001237104,0.00006256181,0.005436623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006830774,"threshold_uncertainty_score":0.036125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04960590199528988,"score_gpt":0.3332655827216463,"score_spread":0.2836596807263564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}