{"id":"W3041807032","doi":"10.2196/19456","title":"Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial","year":2020,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Chiao Tung University; James Cook University; T.A. Sciences","keywords":"Immunosenescence; Acute coronary syndrome; Medicine; Randomized controlled trial; Telomerase; Protocol (science); Telomere; Internal medicine; Oncology; Gerontology; Immunology; Myocardial infarction; Biology; Pathology; Immune system; Alternative medicine; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001702581,0.0004193459,0.001170202,0.0005235354,0.0002443032,0.0001263155,0.0004839344,0.0001665679,0.000193733],"category_scores_gemma":[0.001701496,0.000312159,0.0001678423,0.001728026,0.0003090689,0.0004686939,0.000178415,0.0008845511,0.00008350022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003020749,"about_ca_system_score_gemma":0.001036801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009258054,"about_ca_topic_score_gemma":0.00001245474,"domain_scores_codex":[0.9945287,0.0008262965,0.0009522333,0.0009833348,0.001667424,0.001042042],"domain_scores_gemma":[0.9967201,0.0007349979,0.0002312555,0.0006784872,0.0009479455,0.0006872445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9765,0.003059185,0.002812533,0.001272099,0.00009452031,0.0002317199,0.0006024614,0.00000207939,0.005177623,0.00003585472,0.004747384,0.005464517],"study_design_scores_gemma":[0.9046234,0.04981297,0.01239538,0.004527404,0.0000145173,0.00002003314,0.00008572581,0.0000716356,0.003826487,0.00005096179,0.02413349,0.000437997],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.09047677,2.860749e-7,0.000190441,0.002710086,0.000007615562,0.9063953,0.00002806283,0.0001139869,0.00007744614],"genre_scores_gemma":[0.02581928,2.838828e-7,0.002066614,0.0007369302,0.0001149842,0.9707803,0.00005404996,0.0000875391,0.0003400055],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.07187663,"threshold_uncertainty_score":0.9999331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1532531135223804,"score_gpt":0.4772810043048177,"score_spread":0.3240278907824373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}