{"id":"W3041857881","doi":"10.1111/jcmm.15483","title":"Ageing‐associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca<sup>2+</sup> homeostasis and promotes cardiac dysfunction","year":2020,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Health Research","keywords":"Homeostasis; Phospholamban; Contractility; Mitochondrion; Internal medicine; Endocrinology; Ageing; Biology; Cell biology; Reactive oxygen species; Sodium-calcium exchanger; Glucose homeostasis; Cardiac function curve; Endoplasmic reticulum; Calcium; Medicine; Heart failure; Insulin resistance; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004169227,0.0002422825,0.000535599,0.0001430364,0.00006163469,0.0000210963,0.0001047621,0.0002496619,0.00005177317],"category_scores_gemma":[0.001246012,0.0002016134,0.0001241658,0.0002010899,0.000163736,0.00001281829,0.00007740823,0.0003244216,0.000002215988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002005351,"about_ca_system_score_gemma":0.00008251937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005920342,"about_ca_topic_score_gemma":0.000007656906,"domain_scores_codex":[0.9982014,0.0003696829,0.0005549362,0.0003468794,0.0002740033,0.0002530882],"domain_scores_gemma":[0.9989997,0.00003602847,0.0002781305,0.0001644306,0.0001659428,0.0003557943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004993987,0.00005146381,0.0008867828,0.00005947325,0.0001306196,0.0005199941,0.0006350487,0.00006740745,0.993051,0.00001497923,0.002719718,0.001364094],"study_design_scores_gemma":[0.02648579,0.01623537,0.004265066,0.0009273849,0.001730317,0.001274546,0.004553637,0.004072614,0.8399134,0.0005437389,0.09830236,0.001695724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844332,0.009842332,0.002392089,0.00252087,0.000390039,0.0002516009,0.00001301098,0.000006916846,0.0001499708],"genre_scores_gemma":[0.9956096,0.001834714,0.0003122462,0.001321955,0.0007156724,0.000005457113,0.0001028823,0.00003094316,0.00006653884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1531376,"threshold_uncertainty_score":0.8221554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007754278741351576,"score_gpt":0.2223926780826684,"score_spread":0.2146383993413168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}