{"id":"W3041902060","doi":"10.1016/j.ebiom.2020.102860","title":"Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer","year":2020,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; National Institutes of Health; Faculty of Arts and Sciences; Gary Bennett Family Fund; Bayer Corporation; Research Promotion Foundation; Mitsukoshi Health and Welfare Foundation; Colorectal Cancer Alliance; Conquer Cancer Foundation; George W. Stone Family Foundation; Taiho Pharmaceutical; Entertainment Industry Foundation; Stand Up To Cancer; Uehara Memorial Foundation; National Cancer Institute; Bayer; Gilead Sciences; American Association for Cancer Research; Eli Lilly and Company; Bristol-Myers Squibb; Dana-Farber/Harvard Cancer Center; Merck; Dana-Farber Cancer Institute; Pfizer; Celgene","keywords":"Colorectal cancer; Budding; Biology; Cancer research; Cancer; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006608759,0.0001453956,0.0001877256,0.0005653818,0.000185159,0.0003893501,0.0002276907,0.0002410813,0.0009240527],"category_scores_gemma":[0.002305968,0.0001622587,0.0002012423,0.0005828858,0.0002637307,0.0001989542,0.000359024,0.0002577089,0.0001055001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506155,"about_ca_system_score_gemma":0.000148632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001593779,"about_ca_topic_score_gemma":0.001800732,"domain_scores_codex":[0.9997433,0.00008087431,0.0000236447,0.00007072891,0.00005622333,0.00002527144],"domain_scores_gemma":[0.9981979,0.0004450288,0.0008793233,0.0001596243,0.0001346528,0.0001833984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004076518,0.00001403178,0.9949544,0.00002335337,0.00004912457,0.00003778589,0.0000343195,0.0003911823,0.00170023,0.00003343975,0.00003768476,0.002316838],"study_design_scores_gemma":[0.000004524471,0.00009464932,0.9980844,0.000003815822,0.00002658639,0.0001826227,0.00004623255,0.0008230768,0.0005580354,0.00007620962,0.00009723302,0.000002526944],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993999,0.0002090659,0.0002007891,0.0000136273,8.960106e-7,0.000002632422,0.00006561953,0.000004162557,0.0001033491],"genre_scores_gemma":[0.9997774,0.00002805995,0.0001007182,0.000003898858,0.000001429608,0.000001688536,0.00005079498,0.000001019194,0.00003505998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593779,"threshold_uncertainty_score":0.003495097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439458805733817,"score_gpt":0.2684792686064696,"score_spread":0.2540846805491314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}