{"id":"W3041902060","doi":"10.1016/j.ebiom.2020.102860","title":"Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer","year":2020,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; National Institutes of Health; Faculty of Arts and Sciences; Gary Bennett Family Fund; Bayer Corporation; Research Promotion Foundation; Mitsukoshi Health and Welfare Foundation; Colorectal Cancer Alliance; Conquer Cancer Foundation; George W. Stone Family Foundation; Taiho Pharmaceutical; Entertainment Industry Foundation; Stand Up To Cancer; Uehara Memorial Foundation; National Cancer Institute; Bayer; Gilead Sciences; American Association for Cancer Research; Eli Lilly and Company; Bristol-Myers Squibb; Dana-Farber/Harvard Cancer Center; Merck; Dana-Farber Cancer Institute; Pfizer; Celgene","keywords":"Colorectal cancer; Budding; Biology; Cancer research; Cancer; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002389028,0.0001790261,0.0003719821,0.0001775647,0.00003870272,0.00001162009,0.00007046671,0.00008957298,0.0005450736],"category_scores_gemma":[0.00006708571,0.000139601,0.00004981653,0.0005111494,0.0001642841,0.00004225224,0.00004020892,0.0002099423,0.000007332627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001072617,"about_ca_system_score_gemma":0.0001157821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004035567,"about_ca_topic_score_gemma":0.0000478788,"domain_scores_codex":[0.9988263,0.00006960848,0.0003038047,0.000309596,0.0002251419,0.0002655439],"domain_scores_gemma":[0.9995022,0.00007668965,0.00007552388,0.00008691274,0.00003334096,0.0002253428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03338123,0.00009133673,0.02121953,0.0001086853,0.0000593457,0.0001677223,0.002091354,3.927948e-7,0.933529,8.691512e-7,0.006506278,0.002844277],"study_design_scores_gemma":[0.02815549,0.004503781,0.8463459,0.0006170861,0.0001628731,0.00008864512,0.001253501,0.001487948,0.1024939,0.000006457868,0.01452178,0.000362635],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690644,0.003472659,0.0000278182,0.02649626,0.0002007135,0.0003623907,0.0000199584,0.00006158167,0.0002941832],"genre_scores_gemma":[0.9944636,0.0004693091,0.00005424883,0.004341103,0.0002202243,0.00002222991,0.00003032855,0.00002489997,0.0003740168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8310351,"threshold_uncertainty_score":0.5968174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439458805733817,"score_gpt":0.2684792686064696,"score_spread":0.2540846805491314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}