{"id":"W3041904195","doi":"10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2315","title":"Crosstalk Between the Glucocorticoid Receptor, NF-κB and P38 MAPK in Pulmonary Epithelial Cells Enables Increased Inflammatory Signaling Due to Enhanced Toll-Like Receptor 2 Expression","year":2020,"lang":"en","type":"article","venue":"","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Crosstalk; Toll-like receptor; Glucocorticoid receptor; p38 mitogen-activated protein kinases; Signal transduction; NF-κB; MAPK/ERK pathway; Cell biology; Receptor; Glucocorticoid; Chemistry; Cancer research; Innate immune system; Biology; Medicine; Immunology; Internal medicine; Electronic engineering; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003299009,0.0003166716,0.0005473993,0.0001447968,0.0001872694,0.00008891306,0.000182521,0.0001589205,0.001688334],"category_scores_gemma":[0.0002394537,0.0002262203,0.0001301328,0.0003436022,0.00007946133,0.0002095929,0.0001922005,0.0004791274,0.0002651271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009239988,"about_ca_system_score_gemma":0.0001626554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000244186,"about_ca_topic_score_gemma":0.00001640707,"domain_scores_codex":[0.9977756,0.0001465352,0.0007011087,0.0005848738,0.000366752,0.000425107],"domain_scores_gemma":[0.998556,0.0004207106,0.0001522281,0.000342783,0.0001158895,0.0004123597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006788863,0.00007717314,0.002523359,0.0001179888,0.00003348866,0.00003818734,0.001332248,0.00008242794,0.9906839,0.0000108199,0.002231055,0.002190492],"study_design_scores_gemma":[0.001074514,0.000352184,0.001772115,0.0003936736,0.00004105458,0.00001187144,0.001239168,0.000219794,0.9670058,0.00001540522,0.0275992,0.0002752572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940906,0.0001195489,0.001262898,0.00193316,0.0002981256,0.001069261,0.00008408727,0.000126565,0.001015719],"genre_scores_gemma":[0.9951044,0.00004213473,0.001392605,0.001938352,0.000818275,0.00008776094,0.00007954656,0.00005593112,0.0004809746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02536814,"threshold_uncertainty_score":0.9992242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685263158547995,"score_gpt":0.248056610725788,"score_spread":0.231203979140308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}