{"id":"W3041904195","doi":"10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2315","title":"Crosstalk Between the Glucocorticoid Receptor, NF-κB and P38 MAPK in Pulmonary Epithelial Cells Enables Increased Inflammatory Signaling Due to Enhanced Toll-Like Receptor 2 Expression","year":2020,"lang":"en","type":"article","venue":"","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Crosstalk; Toll-like receptor; Glucocorticoid receptor; p38 mitogen-activated protein kinases; Signal transduction; NF-κB; MAPK/ERK pathway; Cell biology; Receptor; Glucocorticoid; Chemistry; Cancer research; Innate immune system; Biology; Medicine; Immunology; Internal medicine; Electronic engineering; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002894775,0.0003659992,0.0002740099,0.000209071,0.0002353294,0.0005860826,0.0002006585,0.0003465662,0.002286951],"category_scores_gemma":[0.0001739369,0.0001933704,0.0003162979,0.0001708713,0.0002598285,0.0004136182,0.0004104338,0.0006716138,0.00041288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003070834,"about_ca_system_score_gemma":0.0003286118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002728025,"about_ca_topic_score_gemma":0.0006495626,"domain_scores_codex":[0.9994778,0.0001283102,0.00002997895,0.00007561099,0.0001008523,0.000187461],"domain_scores_gemma":[0.9998758,0.00002069161,0.0000268823,0.0000166931,0.00001137519,0.00004859602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001629519,0.00001770534,0.0001857554,0.00002692316,0.000003211137,0.00004851732,0.00001552796,0.00002094359,0.9989498,0.0001062699,0.00001996789,0.0004425211],"study_design_scores_gemma":[0.00003951217,0.0004518643,0.008849888,0.00001065177,0.00002328985,0.0004179644,0.000191344,0.0007252812,0.9870252,0.0001919759,0.002064905,0.00000802146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934701,0.002171289,0.002536281,0.000270014,0.00007683854,0.00001676098,0.0002034025,0.00005484045,0.001200569],"genre_scores_gemma":[0.9973023,0.0004505968,0.0009932794,0.000049276,0.00001892369,0.00002025265,0.0001099196,0.000005544121,0.001049894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002286951,"threshold_uncertainty_score":0.007650554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685263158547995,"score_gpt":0.248056610725788,"score_spread":0.231203979140308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}