{"id":"W3041936813","doi":"10.1016/j.jpeds.2020.07.031","title":"Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension","year":2020,"lang":"en","type":"article","venue":"The Journal of Pediatrics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Advancing Translational Sciences; Agency for Healthcare Research and Quality","keywords":"Medicine; Portal hypertension; Liver transplantation; Liver disease; Cholestasis; Internal medicine; Hazard ratio; Cohort; Transplantation; Neonatal cholestasis; Model for End-Stage Liver Disease; Alpha 1-antitrypsin deficiency; Cohort study; Pediatrics; Biliary atresia; Gastroenterology; Cirrhosis; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000628671,0.0002857551,0.0004543761,0.0005977377,0.0006006669,0.0007369372,0.0002747647,0.0004951367,0.001072809],"category_scores_gemma":[0.00320604,0.0002226383,0.000393861,0.000773786,0.0002757858,0.001044419,0.0004993865,0.001158306,0.0002927989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002802564,"about_ca_system_score_gemma":0.0005959274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004493008,"about_ca_topic_score_gemma":0.004646239,"domain_scores_codex":[0.9997097,0.0000690404,0.00003458147,0.00005068722,0.00004315414,0.00009284139],"domain_scores_gemma":[0.9974545,0.0004883319,0.0008158803,0.0001591227,0.0002412427,0.0008409181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006273968,0.00002262131,0.9989717,0.000001761577,0.000009292529,0.0001356531,0.00003256401,0.00001261082,0.0001129845,0.000009021414,0.00003112849,0.0005979629],"study_design_scores_gemma":[0.000002172368,0.0001901184,0.9987794,0.000004376831,0.00001333277,0.0006121864,0.0001296771,0.00009473889,0.00007153217,0.00002905571,0.00007063431,0.000002858938],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990703,0.0001849121,0.00009404685,0.00007076682,0.000007134692,0.000003304853,0.0002179279,0.000005254189,0.0003463647],"genre_scores_gemma":[0.9991021,0.0001734154,0.00007533479,0.00003153071,0.00001274136,0.000005001668,0.0004278007,0.000002990101,0.0001691241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004493008,"threshold_uncertainty_score":0.008933663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376197811102324,"score_gpt":0.2143776340837849,"score_spread":0.2006156559727617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}