{"id":"W3041938320","doi":"10.1016/j.jaci.2020.06.032","title":"A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)","year":2020,"lang":"en","type":"letter","venue":"Journal of Allergy and Clinical Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Cincinnati Children’s Research Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Sting; Genetics; Pediatrics; Medicine; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0009393255,0.0005019688,0.002266321,0.0004273911,0.0001073404,0.00002134253,0.0006485914,0.002173027,0.0002469439],"category_scores_gemma":[0.003092872,0.0003697331,0.0004791894,0.0002743489,0.00102998,0.0001496654,0.0002728833,0.006113111,0.00001821527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006571051,"about_ca_system_score_gemma":0.0007768042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002096457,"about_ca_topic_score_gemma":0.0003486002,"domain_scores_codex":[0.9947923,0.001308681,0.002727234,0.0004424992,0.0001181241,0.0006111485],"domain_scores_gemma":[0.9929375,0.002854587,0.003271827,0.0003336525,0.0005630633,0.00003935326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1143392,0.01081875,0.02563022,0.000855962,0.1594521,0.02423189,0.01377323,0.00001928455,0.05973902,0.0005416061,0.5634054,0.02719333],"study_design_scores_gemma":[0.05016803,0.05258311,0.1809616,0.009036493,0.002462789,0.01901994,0.002905938,0.00001413859,0.004274476,0.00107963,0.6749066,0.002587204],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.839068,0.02075265,0.0002573987,0.135051,0.003739342,0.0005123832,0.0001880539,0.00005048349,0.0003807005],"genre_scores_gemma":[0.7437052,0.03975604,0.001044241,0.2088006,0.00125916,0.00004344643,0.0005771659,0.0003164018,0.004497834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1569893,"threshold_uncertainty_score":0.9998755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02663963607735433,"score_gpt":0.292213109980065,"score_spread":0.2655734739027107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}