{"id":"W3041967090","doi":"10.1007/s12551-020-00717-1","title":"Synthetic biology approaches to dissecting linear motor protein function: towards the design and synthesis of artificial autonomous protein walkers","year":2020,"lang":"en","type":"review","venue":"Biophysical Reviews","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Vetenskapsrådet; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse; European Commission","keywords":"Membrane biology; Synthetic biology; Function (biology); Protein design; Biological system; Computer science; Biophysics; Biology; Computational biology; Cell biology; Biochemistry; Protein structure; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005163125,0.0004799325,0.001416405,0.00004669643,0.00007900621,0.00002438229,0.0003490907,0.00027493,0.000006678012],"category_scores_gemma":[0.001020704,0.0002999957,0.0005275854,0.000242857,0.0001305761,0.000002207465,0.0002201001,0.0002367115,0.00002896547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002190368,"about_ca_system_score_gemma":0.0001412849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006529916,"about_ca_topic_score_gemma":7.603381e-7,"domain_scores_codex":[0.9977118,0.0004656827,0.0007215501,0.0007117304,0.0001031033,0.000286102],"domain_scores_gemma":[0.9989207,0.00007365687,0.0002794944,0.0005443649,0.00003315467,0.0001485883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002820227,0.00004537752,3.307875e-8,0.004511793,0.00009797328,6.94974e-7,0.00001488805,0.000005548117,0.03663355,0.0001419927,0.00002869642,0.9584913],"study_design_scores_gemma":[0.0000358501,0.0005275075,5.28164e-7,0.002545534,0.0004285365,0.000005572117,0.000009393223,0.0001775249,0.02268418,0.00002744335,0.9731774,0.0003805157],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001511643,0.9419332,0.0531716,0.000113583,0.0001021953,0.004447816,0.00003175073,0.00001808961,0.00003066471],"genre_scores_gemma":[0.002670073,0.9821926,0.01009702,0.00003001954,0.001343349,0.003400798,0.00003894231,0.0001066886,0.0001205118],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9731487,"threshold_uncertainty_score":0.9999452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1193811276486679,"score_gpt":0.3302760907948187,"score_spread":0.2108949631461508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}