{"id":"W3041971789","doi":"10.1111/sji.12929","title":"Metabolic optimization of adoptive T cell transfer cancer immunotherapy: A historical overview","year":2020,"lang":"en","type":"article","venue":"Scandinavian Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Adoptive cell transfer; Cytotoxic T cell; Immunotherapy; Cancer immunotherapy; Cancer research; Biology; CD8; T cell; Immunology; Cell biology; Antigen; Biochemistry; In vitro; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002626569,0.0001771041,0.0008963739,0.0002476973,0.00003317955,0.000007876658,0.000244807,0.0001492503,0.005303257],"category_scores_gemma":[0.00003517017,0.0001445665,0.0003725128,0.0004565902,0.0001384754,0.0001094086,0.00002330429,0.0006029975,0.000004847242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003715073,"about_ca_system_score_gemma":0.0003742381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009678669,"about_ca_topic_score_gemma":0.000001746202,"domain_scores_codex":[0.9982834,0.0002123279,0.0006971289,0.0001652908,0.000357976,0.0002839178],"domain_scores_gemma":[0.9988622,0.00005416958,0.0002544099,0.0001881778,0.0004770324,0.0001639823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01130103,0.0005035162,0.006332317,0.000192898,0.001596016,0.0001703213,0.005111536,0.001146002,0.9076472,0.0001372082,0.0008595314,0.06500242],"study_design_scores_gemma":[0.04766447,0.02423669,0.03685968,0.001180608,0.001892962,0.001913637,0.001989812,0.001163463,0.6190335,0.0001661097,0.2628272,0.001071955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6275278,0.3438739,0.01344478,0.0119234,0.001032764,0.0007853823,0.00002484529,0.00004943709,0.001337673],"genre_scores_gemma":[0.9410133,0.05521164,0.001813397,0.000658177,0.0003535576,0.00001037977,0.000005086209,0.00008356223,0.0008508928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3134855,"threshold_uncertainty_score":0.995606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04227273855186823,"score_gpt":0.3049493309169022,"score_spread":0.262676592365034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}