{"id":"W3041993961","doi":"10.1101/2020.07.13.20152025","title":"Time course of phosphorylated tau181 in blood across the Alzheimer’s disease spectrum","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wallenberg Centre for Molecular and Translational Medicine; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Genentech; National Institutes of Health; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; Orionin Tutkimussäätiö; European Commission; Hjärnfonden; Vetenskapsrådet; Eisai; Ministerio de Ciencia, Innovación y Universidades; Northern California Institute for Research and Education; Servier; Knut och Alice Wallenbergs Stiftelse; Pfizer; Biogen; BioClinica; University of Southern California; BrightFocus Foundation; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Gun och Bertil Stohnes Stiftelse; Bristol-Myers Squibb; Demensförbundet; Novartis Pharmaceuticals Corporation; Alzheimerfonden; Alzheimer's Drug Discovery Foundation; Alzheimer's Association","keywords":"Biomarker; Disease; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Dementia; Medicine; Positron emission tomography; Cohort; Prospective cohort study; Internal medicine; Amyloid (mycology); Alzheimer's disease; Cerebrospinal fluid; Longitudinal study; Oncology; Cognitive decline; Pathology; Psychology; Neuroscience; Nuclear medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004703494,0.0002682229,0.0003752885,0.0006707979,0.0003893556,0.0005407043,0.0002383498,0.0004558996,0.0007552037],"category_scores_gemma":[0.001446139,0.0002284228,0.0002023371,0.0006597693,0.0001840971,0.0004351471,0.0002942538,0.0004542867,0.0002234313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002070345,"about_ca_system_score_gemma":0.0001211548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002088078,"about_ca_topic_score_gemma":0.001565768,"domain_scores_codex":[0.9997645,0.00004245187,0.00001827616,0.0001018123,0.00003953365,0.00003339058],"domain_scores_gemma":[0.9991373,0.0001341895,0.0003582582,0.00006661504,0.0001725286,0.0001310522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002461175,0.0001249741,0.9842235,0.00002454507,0.0001150025,0.0002912914,0.0002721169,0.0001116989,0.007566015,0.00004031409,0.0002051826,0.004564107],"study_design_scores_gemma":[0.000009399732,0.0002190282,0.9985398,0.00000297662,0.00002079567,0.0002534202,0.00007568691,0.000160484,0.000537351,0.00004626648,0.0001305394,0.000004185267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990584,0.0002150235,0.0001293926,0.00001916477,0.000003009762,0.000004881912,0.0003957518,0.000007169919,0.00016723],"genre_scores_gemma":[0.9989384,0.00008507002,0.0001565589,0.00001762366,0.000006839191,0.00001201037,0.0005716513,0.000002953688,0.0002090278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002088078,"threshold_uncertainty_score":0.004151821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02875311537320855,"score_gpt":0.3359069334944044,"score_spread":0.3071538181211958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}